1. We have considered the spinal cord and the PNS…so

2. …to the brain! Many ways to organize the brain Here’s a good one!

3. How about this one?

4. Let’s start with this one. Brainstem Midbrain Basal Forebrain Thalamus, hypothalamus, Basal ganglia, limbic system Cerebral Cortex

5. BRAINSTEM/ HINDBRAIN MAJOR STRUCTURES- Medulla Oblongata Cerebellum and Pons “The Reticular Formation” (sometimes called the reticular activating system) A “Mid-sagital view”

6. functions of the Medulla Oblongata- focus on the Vagus nerve.. All parasympathetic tone –HR Temp BP Etc

7. Brainstem: The “Reticular activating system” Many tiny brain nuclei collectively involved in modulation of arousal brain nuclei- refers to organized groupings of neuron cell bodies

8. Representative Nuclei of The RAS- the Locus Coereleus The LC Projects to cerebral cortex- critical in cognitive orienting Projects – a term referring to the connection path of axons from one nuclei to other brain nuclei

9. RAS- the Raphe Nucleus Raphe Nucleus – High in Serotonin (5HT) involved in Modulation of mood, sleep states, dreaming…SSRIs primary site of action.

10. BRAINSTEM- Pons and Cerebellum In general the cerebellum acts to produce automatic coordination of behavior and behavioral sequences.

11. Midbrain Major structures of interest: Substantia nigra- high Dopamine (DA) content- critical in voluntary movement Peri-aqueductal grey (PAG) - high in endorphin content- modulation of pain Ventral tegmental area (VTA)- high in DA content- critical in “wanting/cravings” components of behavior

12. Midbrain- The ventral tegmental area (VTA)

13. VTA to Nucleus Accumbens: The Mesolimbic Dopamine pathway- Wanting or “reward?”

14. Basal Forebrain Structures Thalamus and Hypothalamus (Diencephalon)

15. The Thalamus The thalamus relays sensory information from sense organs to the cerebral cortex

16. The Hypothalamus Rostral and slightly inferior to the thalamus. - Involved in modulation of the 4 F’s Fighting Fleeing (flight) Feeding Mating

17. BASAL FOREBRAIN Basal Ganglia- important for initiation and control of stereotyped/automatic behaviors like walking, arm movements etc… Neostriatum Globus Pallidus ( GLOB-us PAL-i-dos) Substantia nigra …? Isn’t this part of the midbrain? Yes, but is functionally part of the basal ganglia

18. Nigro-striatal Dopamine system The substantia nigra projects to the striatum

19. Parkinsons’- progress cell death/loss in the substantia nigra Slowness of movement (bradykinesia) Shuffling gait Stiffness (rigidity) Tremor Loss of balance (postural instability) Speech and facial expression Damage to the Nigro-striatal DA system?

20. Typical Parkinsons’ MOST DIFFICULT SYMPTOM- Difficulty in initiation and/or changing of behavior For this reason we can think of the nigro-striatal DA pathway to NORMALLY be critical for….. Behavior initiation, the green light system, the behavioral “grease.”

21. **of interest?? TREMORS AT REST <param name="movie" value="http://www.youtube.com/v/gboQaXv9CuM"><param name="allowFullScreen" value="true"> <embed src="http://www.youtube.com/v/gboQaXv9CuM" type="application/x-shockwave-flash" allowfullscreen="true" allowScriptAccess="always" width="425" height="344">

22. When things go wrong in the Globus pallidus ?? Huntington's Chorea- uncontrollable continuous snake-like, dance-like writhing movements, involving the entire body Basal Ganglia- The Globus Pallidus Critical for inhibiting stray/unauthorized behaviors

23. Huntington's Chorea is principally characterized by hyperkinesias - abnormal, purposeless, involuntary motor movements that can occur spontaneously or only when the patient is trying to do something. These movements may be repetitive or non-repetitive.

24. When things go wrong in the Globus pallidus ?? Tourettes Syndrome- Tics TS usually becomes apparent in children between ages 2 to 15, with approximately 50% of patients affected by age 7. The age of symptom onset is typically before the age of 18. TS is more frequent in males than females by a ratio of about 3 or 4 to 1. The disorder is thought to affect 0.1% to 1.0% of individuals in the general population.

25. Tourettes Syndrome TS usually becomes apparent in children between ages 2 to 15, with approximately 50% of patients affected by age 7. The age of symptom onset is typically before the age of 18. TS is more frequent in males than females by a ratio of about 3 or 4 to 1. The disorder is thought to affect 0.1% to 1.0% of individuals in the general population.

26. Tourettes Motor tics Initially, patients develop sudden, rapid, recurrent, involuntary movements (motor tics), particularly of the head and facial area. At symptom onset, motor tics usually consist of abrupt, brief, isolated movements known as simple motor tics, such as repeated eye blinking or facial twitching. Simple motor tics may also include repeated neck stretching, head jerking, or shoulder shrugging. Less commonly, motor tics are more "coordinated," with distinct movements involving several muscle groups, such as repetitive squatting, skipping, or hopping. These tics, referred to as complex motor tics, may also include repetitive touching of others, deep knee bending, jumping, smelling of objects, hand gesturing, head shaking, leg kicking, or turning in a circle. In addition to affecting the head and facial area, motor tics also affect other parts of the body, such as the shoulders, torso, arms, and legs. The anatomical locations of motor tics may change over time. Rarely, motor tics evolve to include behaviors that may result in self-injury, such as excessive scratching and lip biting.

27. Vocal tics Vocal tics are sudden, involuntary, recurrent, often relatively loud vocalizations. Vocal tics usually begin as single, simple sounds that may eventually progress to involve more complex phrases and vocalizations. For example, patients may initially develop simple vocal tics, including grunting, throat clearing, sighing, barking, hissing, sniffing, tongue clicking, or snorting. Complex vocal tics may involve repeating certain phrases or words out of context, one's own words or sounds (palilalia), or the last words or phrases spoken by others (echolalia). Rarely, there may be involuntary, explosive cursing or compulsive utterance of obscene words or phrases (coprolalia).

28. Other Basal Ganglia related disorders Balisms

29. LIMBIC SYSTEM Interconnected Affective impulses low consciousness Reciprocally connected with frontal cortex –Many structures Hippocampus Amygdala Nucleus accumbens

30. View of some limbic system structures

31. Hippocampus (seahorse?) Based on early neuroanatomical observations and studies with psychoactive drugs, the septohippocampal circuit has been proposed as a model for anxiety disorders. Note*-Memory processes can be profoundly affected by life experiences. In particular, stress has proved to be a major modulator of memory function. 1–4 1–4

32. Hippocampus and Memory: “H.M.” Henry Gustav Molaison, lost completely the ability to form new memories following a radical surgical procedure to treat his severe and intractable epilepsy. profound anterograde and retrograde amnesia 1953; William Scoville, a neurosurgeon removed both of H.M.'s hippocampi in their entirety, together with some of the surrounding structures. H.M.'s amnesia was so severe that he never recognized Dr. Brenda Milner, despite working with her for more than 50 years.

33. View of some limbic system structures

34. The Amygdala receives input from many other brain areas that would logically allow evaluation of emotional significance of experiences

35. CORTEX

36. CEREBRAL CORTEX Wrinkled Thin Layered Interconnected Plastic ( consider vs brainstem)

37. Cortical hemispheres

38. Corpus collosum

39. Functional asymmetries? Roughly 90% of right handers, and 70% of left handers

40. Assertions based on data Left hemisphere- analytical, rational, verbal, reading, writing,math Right Hemisphere- Intuitive, feeling, spatial processing, nonverbal, music

41. LOBES- gyri and sulci

42. OCCIPITAL LOBE primary visual processing-

43. Temporal Lobes Primary auditory cortex  Hearing  Understanding language (receptive language)  Higher visual processing

44. Parietal Lobes

45. Parietal Lobe  Primary somatosensory cortex  Visuo-spatial processing

46. Primary Somatosensory Ctx The sensory homunculus The “post central gyrus”

47. Somatosagnosias- perception of reality depends on CTX Unilateral neglect anosagnosias

48. RX for Phantom limb- awareness arises from cortex independently of reality.

49. FRONTAL LOBES

50. Primary motor cortex- precentral gyrus more later

51. Frontal Lobe functions Volitional behavior Speech Inhibition of impulses Self-control/temptations Self-initiative Planning/anticipation Self-monitoring Awareness (abilities and limitations) Attention Mental flexibility Problem solving Complex Judgments/goal setting Source monitoring Self-identity Copying Working memory Temporal memory- sequencing Emotion

52. Suppression of Impulses Some scientists contend that the prefrontal cortex normally acts to suppress or act upon urges or impulses perhaps by communicating with other brain areas that mediate fear and aggression, such as the amygdala.