1. High level of low density lipoprotein cholesterol in adult children of patients with premature coronary heart disease: relation to own and parental characteristics MV. Konnov, LM. Dobordzhginidze, AD. Deev, NA. Gratsiansky Center for Atherosclerosis, Institute Of Physico-Chemical Medicine, Moscow, Russian Federation Conclusions Independent predictors of high LDL-C in adult childrenOR95% CIP LDL cholesterol of proband - parent, mmol/l1.461.12 to 1.910.005 LDL cholesterol of consort - parent, tertile 3 (≥4.42 mmol/l) vs tertile 1 (<3.71 mmol/l) 5.181.72 to 15.60.003 BMI of consort - parent, tertile 3 (≥29.4 kg/m 2 ) vs tertile 1 (<25.5 kg/m 2 ) 3.361.25 to 9.020.016 own smoking vs non-smoking0.460.24 to 0.880.018 In this group of adult children with parental premature CHD: (1)LDL-C level of proband-parent was independently associated with high LDL-C; (2)However characteristics of consort-parent (LDL-C and BMI) were also independently related to high LDL-C in their adult children. For further information or comments: konnov-mihail@yandex.ru Factors related (with p<0.1) to high LDL-C in adult childrenOR95% CIP LDL cholesterol of proband - parent, mmol/l1.461.12 to 1.910.005 LDL cholesterol of consort - parent, mmol/l1.831.17 to 2.860.008 metabolic syndrome of consort – parent2.661.22 to 5.810.014 BMI of consort - parent, kg/m 2 1.101.02 to 1.180.015 own smoking0.740.59 to 0.950.016 waist circumference of consort - parent, cm1.041.01 to 1.080.017 own diastolic BP, mm Hg1.031.00 to 1.060.054 own BMI, kg/m 2 1.060.99 to 1.120.086 Table 1. Results of univariate analysis Table 2. Results of multivariate analysis Background High level of low density lipoprotein cholesterol (LDL-C) can be a critical contributor to elevated risk of coronary events in children of patients with premature coronary heart disease (CHD) *cut point was taken arbitrarily *Criterion of high LDL-C = ≥3.36 mmol/l (130 mg/dl) Material We examined members of 179 families. There were 171 parents-probands (65.2% men, 72.9% after MI) aged 40-63 years, their 113 consorts (24.1% men, 6.57% with CHD) aged 37-67 years and 215 probands children (50.7% men) aged 18-37 years without overt vascular disease. Parameters registered alcohol consumption, tobacco smoking,, oral contraceptive use, height, body mass index (BMI), waist circumference (WC), heart rate, systolic and diastolic blood pressure (BP), total and high density lipoprotein cholesterol, LDL-C, triglycerides, basal serum glucose, impaired glucose tolerance, diabetes mellitus (ADA criteria), arterial prehypertension and hypertension, metabolic syndrome (MS, IDF criteria), use triglyceride and LDL-C lowering drugs and (in parents) education level and presence of menstruation. Purpose To elucidate associations between high LDL-C in adult children of patients with premature (onset <55 years, men; <60 years, women) CHD and their own and parental characteristics. Methods Body mass index (BMI) was calculated as follows: body mass (kg)/height (m 2 ). Low density lipoprotein cholesterol was calculated with Friedwald‘s formula. High BP was defined as arterial prehypertension or hypertension (JNC-7 criteria). For diagnosis impaired glucose intolerance (IGT) and diabetes mellitus (DM) was used oral glucose tolerance test (WHO criteria). Before logistical regression for reduction of continuous coronary risk factors variability and to suppress possible outliers the symmetric censoring of 1% of their values was carried out. High LDL-C was defined as 3.36 mmol/l, its predictors were selected by binary logistical regression analysis with adjustment for age and sex. Results Adult children with LDL-C ≥3.36 mmol/l (41/84 [48.8% men]) – 84/215 (39.1%) with LDL-C <3.36 mmol/l (68/131 [51.9% men]) – 131/215 (60.9%) 39.1% 60.9%