1. The Cell Migration Consortium 5 min; 8hr PD 8 www.cellmigration.org

2. Why Cell Migration? Cancer Osteoporosis Atherosclerosis Tissue Repair & Regeneration Birth Defects Arthritis Tissue Engineering CELL MIGRATION

3. Cell Migration – Complex and Integrative 30 sec; 2hrs

4. Origins of the Consortium There exist significant ‘barriers to progress’ that inhibit progress in migration (and other) research These barriers are beyond the intellectual and financial resources of individual investigators The NIGMS “Glue Grant” initiative provided a mechanism to address these barriers -require collaborative, interdisciplinary approaches -not readily supported by the R01 mechanism

5. Glue grant - objectives Non R01 type research Multi-institutional collaborations Complex processes - Not hypothesis driven, few experiments - reagents, technology, information, & measurements

6. Glue grant - expectations Robust data sharing Significant bioinformatics via website - Organize information in the field - Protocols, data, papers, links, & information Clear objectives and milestones

7. Consortium Objectives Create a “virtual institute” - multi-institutional, interdisciplinary research initiatives and facilities Develop innovative, cutting edge technologies and reagents and produce important new data Develop web-based communications for collaborative interactions information sharing Promote interdisciplinary research Promote synergy among initiatives and facilities

8. Consortium Research Goals A census of the migration proteome The structure of the large multi-molecular complexes that drive migration Probes and technology to locate, quantify, & perturb signals that are regulated spatially and temporally Mathematical models of migration Conditional knockout and knockin mice and cell lines for key migration related genes Imaging technology for studying migration in vivo

9. Bioinformatics goals Organize information & data - Simple, useful, & databases - Migration knowledge database Annotation environment Evidence codes – gene ontology Readily queried

10. Outreach to the Community Timely sharing of reagents, information and data Organize information via the comprehensive website Sponsor migration meetings and workshops Unify the migration community Promote new interdisciplinary interactions Community participation –New opportunities and objectives –New collaborators

11. Organization