1. Journal Club 亀田メディカルセンター 糖尿病内分泌内科 Diabetes and Endocrine Department, Kameda Medical Center 松田 昌文 Matsuda, Masafumi 2009 年 2 月 12 日 8:20-8:50 B 棟８階 カンファレンス室 Szendroedi J, Anderwald C, Krssak M, Bayerle-Eder M, Esterbauer H, Pfeiler G, Brehm A, Nowotny P, Hofer A, Waldhäusl W, Roden M. Effects of high-dose simvastatin therapy on glucose metabolism and ectopic lipid deposition in nonobese type 2 diabetic patients. Diabetes Care. 2009 Feb;32(2):209-14 Djoussé L, Gaziano JM, Buring JE, Lee IM. Egg consumption and risk of type 2 diabetes in men and women. Diabetes Care. 2009 Feb;32(2):295-300.

2. the 1Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria; the 2Karl- Landsteiner Institute of Endocrinology and Metabolism, Vienna, Austria; the 3Department of Medicine/ Metabolic Diseases, Institute for Clinical Diabetology, German Diabetes Center, Heinrich Heine University, Du¨ sseldorf, Germany; the 4Department of Radiology, Medical University of Vienna, Vienna, Austria; the 5Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria; and the 6Division of Special Gynecology, Medical University of Vienna, Vienna, Austria. Diabetes Care 32:209–214, 2009

5. Chol=mg/dl x 0.0259 (mmol/L) 、 TG=mg/dl x 0.0113 (mmol/L)

8. CONCLUSIONS High-dose simvastatin treatment has no direct effects on whole- body or tissue-specific insulin action and ectopic lipid deposition. A reduction in plasma FFAs probably mediates alterations in insulin sensitivity in vivo.

10. the 1 Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts; the 2 Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts; the 3 Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Jamaica Plain, Massachusetts; the 4 Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts; and the 5 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Diabetes Care 32:295–300, 2009

15. These data suggest that high levels of egg consumption (daily) are associated with an increased risk of type 2 diabetes in men and women. Confirmation of these findings in other populations is warranted. CONCLUSIONS