1. Chapter 9 Mood Disorders Clinical Neuroscience by Kelly Lambert and Craig Howard Kinsley Clinical Neuroscience by Kelly Lambert and Craig Howard Kinsley

2. Mood Disorders: An Overview

3. Major Depression in Context Sex Differences and Sociocultural Influences Sex Differences and Sociocultural Influences Genetic Influences and Evolutionary Factors Genetic Influences and Evolutionary Factors

4. Tracing the Neurobiological Roots of Depression Depression’s Neuroanatomical Circuit Depression’s Neuroanatomical Circuit Prefrontal cortex (PFC)Prefrontal cortex (PFC) Hippocampus and amygdalaHippocampus and amygdala Cingulate cortexCingulate cortex Nucleus accumbensNucleus accumbens Brainstem tractsBrainstem tracts White matterWhite matter

5. Tracing the Neurobiological Roots of Depression (cont.) Neurochemistry of Depression Neurochemistry of Depression Serotonin (5-HT)Serotonin (5-HT) Norepinephrine (NE)Norepinephrine (NE) CorticosteroidsCorticosteroids

6. Tracing the Neurobiological Roots of Depression (cont.) Brain Plasticity Brain Plasticity Brain structure and neurogenesisBrain structure and neurogenesis Role of BDNF in depressionRole of BDNF in depression

7. Stress and Depression Life’s Losses Life’s Losses Sexual Abuse in Childhood Sexual Abuse in Childhood Seasonal Changes in Light Seasonal Changes in Light

8. Treatment for Depression Pharmacotherapy Pharmacotherapy Serotonergic manipulationSerotonergic manipulation Noradrenergic manipulationNoradrenergic manipulation Inhibiting corticotropin-releasing factorInhibiting corticotropin-releasing factor

9. Treatment for Depression (cont.) Electroconvulsive Therapy (ECT) Electroconvulsive Therapy (ECT) Repetitive Transcranial Magnetic Stimulation (rTMS) Repetitive Transcranial Magnetic Stimulation (rTMS) Cognitive-Behavioral Therapy Cognitive-Behavioral Therapy

10. Bipolar Disorder Tracing the Neurobiological Roots of Bipolar Disorder Tracing the Neurobiological Roots of Bipolar Disorder Treatment for Bipolar Disorder Treatment for Bipolar Disorder

11. Summary