1. ©2006 Howard Hughes Medical Institute

2. WHY DO RESEARCH? WE NEED YOU! Shortage of physician- scientists in the U.S. Opportunity to improve current therapies and develop new treatment modalities Physician-scientists have unique ability to translate new discoveries from bench to bedside and back Make a difference in patients’ lives

3. ©2006 Howard Hughes Medical Institute WHY DO RESEARCH? CAREER ENHANCEMENT Get into a competitive residency program Gain a faculty position at an academic institution Become a better physician Give back to the community by helping find cures for diseases and saving lives Research Scholar Felix Gonzalez works on a therapeutic intervention for acute myocardial infarction at the National Heart, Lung, and Blood Institute. His research has resulted in upcoming clinical trials and may result in a life-saving intervention for heart patients.

4. ©2006 Howard Hughes Medical Institute U.S. citizenship not required In good standing at a U.S. medical or dental school Not currently enrolled in an M.D./Ph.D. program Cannot have a Ph.D. in a laboratory-based biomedical science Do not have to be from a research-oriented school or have prior research experience Research Scholars Program only: must be legally eligible to work in the United States (Research Scholars become HHMI employees) ELIGIBILITY

5. ©2006 Howard Hughes Medical Institute Your research may be a basic, translational or applied biomedical project. Research Scholars work at the National Institutes of Health (NIH) campus in Bethesda, MD Medical Fellows work at any academic or non-profit research institution in the U.S., except the NIH WHERE DO YOU WANT TO DO RESEARCH?

6. ©2006 Howard Hughes Medical Institute Research Scholars Choose from laboratories at the NIH in Bethesda, Maryland Furnished housing on the NIH campus at the “Cloister” includes housewares, cable TV, internet access, one parking space, and many other amenities Enjoy living in a community with other Scholars RESEARCH LOCATION

7. ©2006 Howard Hughes Medical Institute Medical Fellows Work at any academic or nonprofit research institution in the U.S., except the NIH Research may be conducted abroad if mentor is affiliated with a U.S. institution Spend a year doing research without being displaced from your local surroundings

8. ©2006 Howard Hughes Medical Institute RESEARCH PROJECT Research Scholars Select a project and mentor after you are accepted into the program Receive guidance from an NIH advisor Work with world-class NIH investigators Above: Research Scholar Jayne Joo with her preceptor, Dr. Steven Rosenberg, Chief, Surgery Branch, National Cancer Institute Right: Research Scholar, Brian Capell and his preceptor, Dr. Francis Collins, Director, National Human Genome Research Institute

9. ©2006 Howard Hughes Medical Institute Medical Fellows Mentor and project chosen before you apply Selection of mentor and research project are key components of the application process Opportunity to work with either established or new mentor Medical Fellow, Xavier Garcia-Rojas with his mentor, Dr. Brendan Lee at Baylor College of Medicine

10. ©2006 Howard Hughes Medical Institute SCIENTIFIC TALKS AND MEETINGS Both programs provide you with numerous opportunities to attend scientific talks and meetings to: Learn about the latest scientific discoveries Present your research Network and socialize, with other student researchers and renowned scientists

11. ©2006 Howard Hughes Medical Institute CLOISTER SCIENCE DINNERS Research Scholars Monday night lectures by renowned HHMI and NIH investigators Personal interaction with speakers during reception and dinner Informal discussion after dinner

12. ©2006 Howard Hughes Medical Institute CLOISTER INFORMAL SCIENCE DINNERS Two to three Scholars present their work each week to an all-Scholar audience Receive feedback on your project and suggestions from other Scholars Gain exposure to other fields Practice presenting your work Research Scholars

13. ©2006 Howard Hughes Medical Institute OTHER HHMI SCIENCE EVENTS Special attendance at an HHMI science meeting at Janelia Farm Research Campus with HHMI investigators Scientific Presentations – end of May

14. ©2006 Howard Hughes Medical Institute Medical Fellows Travel to the Washington D.C. area twice during the fellowship year to network and share scientific research Utilize allowances to defray costs of travel to other professional meetings

15. ©2006 Howard Hughes Medical Institute Research Scholars Annual compensation of $25,000, health & life insurance Furnished housing and utilities; computer provided Round-trip moving expense reimbursement Funds for books, courses, and travel to scientific meetings Medical Fellows Annual stipend of $25,000 $5,500 fellow’s allowance may be used for health care and tuition & fees $5,500 research allowance for computer-related expenses, scientific meetings, books, and other research-related expenses FINANCIAL SUPPORT

16. ©2006 Howard Hughes Medical Institute LOAN DEFERMENT Some schools have special status under which students can remain enrolled; fees vary per school Check with registrar and financial aid office For those who do not maintain their enrollment in school, HHMI can help complete deferment forms (request from your loan servicing center) The majority of students defer their loans

17. ©2006 Howard Hughes Medical Institute Research Scholars Deadline: January 10 Project & mentor selected after acceptance into program Select students invited to NIH for interview Internal panel from NIH and HHMI www.hhmi.org/cloister Medical Fellows Deadline: January 11 Must select mentor and write a research plan as part of the application process No interview External review panel of scientists www.hhmi.org/medfellowships You may apply to either or BOTH programs through the same online application system. APPLICATION INFORMATION

18. ©2006 Howard Hughes Medical Institute Research Scholars 168 applicants from 78 schools 82 interviewed from 48 schools 42 accepted from 32 schools Medical Fellows 200 applicants from 54 schools 66 accepted from 26 schools Applications from all qualified candidates are welcome and women and under-represented minorities are encouraged to apply. Females and under-represented minorities are proportionately represented among awardees to both programs. PROGRAM STATISTICS (2006-2007)

19. ©2006 Howard Hughes Medical Institute ALUMNI NETWORK Membership consists of all current and former Fellows and Research Scholars from HHMI’s graduate programs Form collaborations and gain valuable resources for career planning Alumni-organized events throughout the country (e.g., seminars, workshops, socials)