1. Human Anatomy, Larry M. Frolich, Ph.D. Epithelial and Connective Tissues Classes of Tissues –Two classes—epithelial, connective –Muscle and Nervous Tissue (don’t fit in classes) Epithelial tissues –General characteristics –Cell shapes Connective Tissues –General characteristics (areolar) –Types of connective tissues

2. Human Anatomy, Larry M. Frolich, Ph.D. General Types of Tissues Broad Classes of Tissues -Epithelial: sheet of cells. -Connective: cells in a matrix More specific tissue types -do not fit as epithelial or connective -will treat in section two of course -Nervous: carries messages in body -Muscle: effects movement Virtually all organs will have all four types Tissue: a group of closely associated cells that have a similar structure and perform a related function

3. Human Anatomy, Larry M. Frolich, Ph.D. Cells connect, on their lateral surfaces, forming sheets –Gap junctions –Tight junctions –desmosomes Cells can have appendages, on their apical surface, to interact with environment –Cilia –Microvili –Flagella Cells sit, on their basal surface, on a thin basal membrane of collagen fibers for support –Underlying connective tissue further supports epithelium –Blood vessels/nerves travel in underlying connective tissue, nerve endings on epithelium Epithelial Tissues Examples of epithelium: epidermis, lining of gut, mucous membranes, lining of celom, glands

4. Human Anatomy, Larry M. Frolich, Ph.D. Appendages on apical surface Microvilli: (ex) in small intestine –Finger-like extensions of the plasma membrane of apical epithelial cell –Increase surface area for absorption Cilia: (ex) respiratory tubes –Whip-like, motile extensions –Moves mucus, etc. over epithelial surface 1- way Flagella: (ex) spermatoza –Extra long cilia –Moves cell Cilia in tracheaa

5. Human Anatomy, Larry M. Frolich, Ph.D. Connections between epithelial cells Desmosome: binding spots between cells with proteins called cadherins Tight junctions: impermeable –E.g. gut tube, doesn’t let enzymes from gut into blood stream Gap junctions: tubes that let small molecules pass between cells

6. Human Anatomy, Larry M. Frolich, Ph.D. Name that Epithelial Feature! (name and location on cell) Cilia Tight junction Microvilli Basement membrane 2 3 4 1 33 11 22 44

7. Human Anatomy, Larry M. Frolich, Ph.D. Simple: just one layer or cell shape Stratified: multiple layers and cell shapes Classes of Epithelia

8. Human Anatomy, Larry M. Frolich, Ph.D. Simple Epithelia Simple squamous epithelium from alveolus of lung

9. Human Anatomy, Larry M. Frolich, Ph.D. Stratified Epithelia Squamous –E.g. epidermis Transitional epithelium –E.g. urinary structures--bladder –Stretches from 6 cells to 3 cells thick as bladder fills and expands

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11. Can You Identify the Classes of Epithelium? AB C D E Quiz!!

12. Human Anatomy, Larry M. Frolich, Ph.D. Glands: epithelial cells that make and secrete a water-based substance Exocrine Glands –Secrete substance onto body surface or into body cavity –Have ducts –E.G., salivary, mammary, pancreas, liver Endocrine Glands –Secrete product into blood stream –Either stored in secretory cells or in follicle surrounded by secretory cells –Hormones travel to target organ to increase response –No ducts

13. Human Anatomy, Larry M. Frolich, Ph.D. CONNECTIVE TISSUES “Areolar tissue” as model Universal in body Underlies epithelium, supports capillaries, small nn. Always originates from mesenchyme CELLS in MATRIX

14. Human Anatomy, Larry M. Frolich, Ph.D. Extracellular matrix Fibers –Collagen gives structure –Reticular fibers (crossed collagen) gives order –Elastin gives elasticity Ground substance –Jelly-like material made of sugar- protein molecules (proteoglycans)

15. Human Anatomy, Larry M. Frolich, Ph.D. Cells of Connective Tissues Fibroblasts make fibers Immune cells in areolar tissue –Macrophages –Plasma cells –Mast cells –Neutrophils, Lymphocytes

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17. Areolar connective tissue

18. Human Anatomy, Larry M. Frolich, Ph.D. “Loose” connective tissues Adipose tissue mostly under skin and in mesenteries Reticular: organized 3-D network of fibers that support lots of cells –E.g. marrow, spleen, lymph nodes

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20. “Dense” Connective tissues Irregular –Thick fibers running in many planes –E.g. dermis, fibrous capsules around organs Regular –Aligned parallel fibers –Resists tension –E.g. tendon, ligaments, aponeuroses –Sometimes with elastic fibers (e.g. ligamentum nuchae)

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22. Other Connective Tissues Bone Cartilage Blood