1. Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition

2. Copyright © 2009 Pearson Education, Inc. 21.1Whole-Genome Shotgun Sequencing Is a Widely Used Method for Sequencing and Assembling Entire Genomes

3. Copyright © 2009 Pearson Education, Inc. Figure 21.1

4. Copyright © 2009 Pearson Education, Inc. 21.1Whole-Genome Shotgun Sequencing Is a Widely Used Method for Sequencing and Assembling Entire Genomes 21.1.1High-Throughput Sequencing

5. Copyright © 2009 Pearson Education, Inc. Figure 21.2

6. Copyright © 2009 Pearson Education, Inc. 21.1Whole-Genome Shotgun Sequencing Is a Widely Used Method for Sequencing and Assembling Entire Genomes 21.1.2The Clone-by-Clone Approach 21.1.3Draft Sequences and Checking for Errors

7. Copyright © 2009 Pearson Education, Inc. Figure 21.3

8. Copyright © 2009 Pearson Education, Inc. 21.2DNA Sequence Analysis Relies on Bioinformatics Applications and Genome Databases 21.2.1Annotation to Identify Gene Sequences 21.2.2Hallmark Characteristics of a Gene Sequence Can Be Recognized During Annotation

9. Copyright © 2009 Pearson Education, Inc. Figure 21.4

10. Copyright © 2009 Pearson Education, Inc. Figure 21.5

11. Copyright © 2009 Pearson Education, Inc. Figure 21.6a

12. Copyright © 2009 Pearson Education, Inc. Figure 21.6b

13. Copyright © 2009 Pearson Education, Inc. Figure 21.6c

14. Copyright © 2009 Pearson Education, Inc. Figure 21.7

15. Copyright © 2009 Pearson Education, Inc. 21.3Functional Genomics Attempts to Identify Potential Functions of Genes and Other Elements in a Genome 21.3.1Predicting Gene and Protein Functions by Sequence Analysis

16. Copyright © 2009 Pearson Education, Inc. Figure 21.8

17. Copyright © 2009 Pearson Education, Inc. Figure 21.9

18. Copyright © 2009 Pearson Education, Inc. 21.3Functional Genomics Attempts to Identify Potential Functions of Genes and Other Elements in a Genome 21.3.2Predicting Function from Structural Analysis of Protein Domains and Motifs

19. Copyright © 2009 Pearson Education, Inc. 21.4The Human Genome Project Revealed Many Important Aspects of Genome Organization in Humans 21.4.1Origins of the Project 21.4.2Major Features of the Human Genome

20. Copyright © 2009 Pearson Education, Inc.

21. © 2012 Pearson Education, Inc. Table 21.1

22. © 2012 Pearson Education, Inc. Table 21.1

23. Copyright © 2009 Pearson Education, Inc.

24. Figure 21.11

25. Copyright © 2009 Pearson Education, Inc. Figure 21.12a

26. Copyright © 2009 Pearson Education, Inc. Figure 21.12b

27. Copyright © 2009 Pearson Education, Inc. 21.5The “Omics” Revolution Has Created a New Era of Biological Research Methods

28. © 2012 Pearson Education, Inc. Figure 21.13

29. © 2012 Pearson Education, Inc. Personal Genomics The Human Microbiome Project No Genome Left Behind— 10K genomes in 5 years

30. Copyright © 2009 Pearson Education, Inc. 21.6Comparative Genomics Analyzes and Compares Genomes from Different Organisms

31. Copyright © 2009 Pearson Education, Inc. Table 21.2

32. Copyright © 2009 Pearson Education, Inc. Table 21.3

33. Copyright © 2009 Pearson Education, Inc. Figure 21.12

34. © 2012 Pearson Education, Inc. Table 21.3

35. Copyright © 2009 Pearson Education, Inc. Figure 20-8 Copyright © 2006 Pearson Prentice Hall, Inc.

36. Copyright © 2009 Pearson Education, Inc. Figure 21.15

37. Copyright © 2009 Pearson Education, Inc. Table 21.4

38. Copyright © 2009 Pearson Education, Inc. 21.6Comparative Genomics Analyzes and Compares Genomes from Different Organisms The Rhesus Monkey Genome The Sea Urchin Genome The Neanderthal Genome Evolution of Multigene Families

39. Copyright © 2009 Pearson Education, Inc. Figure 21.16

40. Copyright © 2009 Pearson Education, Inc. Figure 21.17

41. Copyright © 2009 Pearson Education, Inc. Figure 21.18

42. Copyright © 2009 Pearson Education, Inc. 21.8Transcriptome Analysis Reveals Profiles of Expressed Genes in Cells and Tissues

43. Copyright © 2009 Pearson Education, Inc. Figure 21.21

44. Copyright © 2009 Pearson Education, Inc. Figure 21.22

45. Copyright © 2009 Pearson Education, Inc. Figure 21.22a

46. Copyright © 2009 Pearson Education, Inc. Figure 21.22b

47. Copyright © 2009 Pearson Education, Inc. 21.9Proteomics Identifies and Analyzes the Protein Composition of Cells Reconciling the Number of Genes and the Number of Proteins Expressed by a Cell or Tissue Proteomics Technologies: Two-Dimensional Gel Electrophoresis for Separating Proteins

48. Copyright © 2009 Pearson Education, Inc. Figure 21.24

49. Copyright © 2009 Pearson Education, Inc. Figure 21.25

50. Copyright © 2009 Pearson Education, Inc. 21.9Proteomics Identifies and Analyzes the Protein Composition of Cells Proteomics Technologies: Mass Spectrometry for Protein Identification

51. Copyright © 2009 Pearson Education, Inc. Figure 21.26

52. Copyright © 2009 Pearson Education, Inc. Figure 21.27

53. Copyright © 2009 Pearson Education, Inc. 21.10Systems Biology Is an Integrated Approach to Studying Interactions of All Components of an Organism’s Cells

54. © 2012 Pearson Education, Inc. Figure 21.29