1. Copyright © 2011, Research To Practice, All rights reserved. National Patterns of Care Study in Breast Cancer Launched October 2010 100 US-based community oncologists surveyed Proportion of patients/office visits with breast cancer: 30% (median) New patients with breast cancer seen per month: 15 (median)

2. Copyright © 2011, Research To Practice, All rights reserved. What percentage of the time did the Oncotype DX ® results cause you to alter your preconceived treatment recommendation? Patterns of Care in Breast Cancer, Research To Practice 2010. Median 010203040 25%

3. Copyright © 2011, Research To Practice, All rights reserved. 60 yo woman: 1.0-cm sentinel node-negative IDC. Which adjuvant chemotherapy treatment would you recommend? Patterns of Care in Breast Cancer, Research To Practice 2010. Tumor Subtype Anthra  TaxaneTCACOtherNone ER+/HER2-neg, would order Oncotype DX (n = 82) High RS Intermediate RS Low RS 30% 7% 0% 60% 62% 4% 6% 4% 0% 4% 1% 3% 0% 26% 93% ER+/HER2-neg, would not order Oncotype DX (n = 18) 0%6%0%6%88%

4. Copyright © 2011, Research To Practice, All rights reserved. 75 yo woman: 1.0-cm sentinel node-negative IDC. Which adjuvant chemotherapy treatment would you recommend? Patterns of Care in Breast Cancer, Research To Practice 2010. Tumor Subtype Anthra  TaxaneTCACOtherNone ER+/HER2-neg, would order Oncotype DX (n = 46) High RS Intermediate RS Low RS 22% 3% 0% 63% 37% 4% 11% 4% 0% 2% 4% 2% 52% 94% ER+/HER2-neg, would not order Oncotype DX (n = 54) 0%11%0%4%85%

5. Copyright © 2011, Research To Practice, All rights reserved. 60 yo woman: 3.4-cm sentinel node-negative IDC. Which adjuvant chemotherapy treatment would you recommend? Patterns of Care in Breast Cancer, Research To Practice 2010. Tumor Subtype Anthra  TaxaneTCACOtherNone ER+/HER2-neg, would order Oncotype DX (n = 64) High RS Intermediate RS Low RS 38% 11% 3% 53% 72% 11% 6% 2% 9% 82% ER+/HER2-neg, would not order Oncotype DX (n = 36) 33%42%11%6%8%

6. Copyright © 2011, Research To Practice, All rights reserved. 75 yo woman: 3.4-cm sentinel node-negative IDC. Which adjuvant chemotherapy treatment would you recommend? Patterns of Care in Breast Cancer, Research To Practice 2010. Tumor Subtype Anthra  TaxaneTCACOtherNone ER+/HER2-neg, would order Oncotype DX (n = 61) High RS Intermediate RS Low RS 16% 3% 2% 69% 46% 6% 5% 3% 2% 7% 5% 3% 43% 85% ER+/HER2-neg, would not order Oncotype DX (n = 39) 5%41%5%13%36%

7. Copyright © 2011, Research To Practice, All rights reserved. 60 yo woman: 1.0-cm IDC (2 positive nodes). Which adjuvant chemotherapy treatment would you recommend? Patterns of Care in Breast Cancer, Research To Practice 2010. Tumor Subtype Anthra  TaxaneTCACOtherNone ER+/HER2-neg, would order Oncotype DX (n = 24) High RS Intermediate RS Low RS 38% 29% 8% 50% 58% 8% 4% 0% 4% 0% 4% 13% 76% ER+/HER2-neg, would not order Oncotype DX (n = 76) 58%24%7%6%5%

8. Copyright © 2011, Research To Practice, All rights reserved. 75 yo woman: 1.0-cm IDC (2 positive nodes). Which adjuvant chemotherapy treatment would you recommend? Patterns of Care in Breast Cancer, Research To Practice 2010. Tumor Subtype Anthra  TaxaneTCACOtherNone ER+/HER2-neg, would order Oncotype DX (n = 44) High RS Intermediate RS Low RS 25% 11% 0% 57% 50% 12% 5% 0% 2% 11% 9% 2% 30% 84% ER+/HER2-neg, would not order Oncotype DX (n = 56) 32%34%7%9%18%