1. Duke NIRL Hosted MIRIAD Data http://nirlarc.duhs.duke.edu Both XNAT and HID

2. Multispectral Segmentation 1.5T and 3T 1.5T Segmentation 3T Segmentation Source scans: proton density, T1-w, T2-w, FLAIR Automated segmentation of gray, white matter, csf and lesion (red). Shown overlaid on proton density image (showing just skull, surface tissues and reference tube outside skull)

3. Lesion Simulation Fractional Contrast for Lesion to White Matter, 3T data PD- weighted T1 weightedT2-weightedFLAIR Mean0.299168-0.129350.882101140.356158 Standard Deviation (SD) of Mean0.0413010.0203950.134351560.097343 SD/Mean0.138053-0.157670.1523085670.273315 VSL=volume of segmented lesion inside of true lesion (True positives) VNSL=volume of nonsegmented lesion inside of true lesion (False negatives) VNL=volume of non-lesion outside of true lesion (True negatives) VLOL=volume of segmented lesion outside of true lesion (False positives) sensitivity=VSL/(VSL+VNSL) specificity=VNL/(VNL+VLOL) accuracy=VSL/(VSL+VLOL) For this example we have sensitivity = 0.73, specificity = 0.89 and accuracy=0.46.

4. SENSE DTI Image Distortion Correction B 0 and eddy current maps distorted SENSE DTI images corrected SENSE DTI images difference

5. AVID software for fMRI-guided fiber tracking

6. Toward Quantitative Fiber Volume Measurement Left Column: Conventional Euler’s method Right Column: Improved streamline tracking method with RK4 algorithm.

7. Unit Hausdorff Distance vs NEX

8. = FA>0.3 FA vs NEX

9. FA=0.32 FA=0.31 Deviation Angle vs NEX FA=0.30FA=0.27 = FA>0.3