1. Venugopalan Lab Photons and Transport vvenugop@uci.edu http://www.eng.uci.edu/users/vasan-venugopalan vvenugop@uci.edu http://www.eng.uci.edu/users/vasan-venugopalan Venugopalan Lab Photons and Transport vvenugop@uci.edu http://www.eng.uci.edu/users/vasan-venugopalan vvenugop@uci.edu http://www.eng.uci.edu/users/vasan-venugopalan Research Summary : Venugopalan laboratory activities center around the study of photon transport, photo-induced thermal and mechanical transport processes, and their application to non- invasively image, characterize, and/or manipulate biological systems across spatial scales. Our group is highly multi-disciplinary with expertise spanning from applied mathematics, physics, and chemistry on one end to chemical engineering, biomedical engineering, and materials science on the other. Areas of current interest include: 1.Mathematical and computational analysis of light transport in cells and tissues with applications to thick tissue imaging and non-invasive measurement of tissue structure, composition, and function. 2.Development of highly-focused laser microbeam technologies for targeted cellular separation, injection, and mechanical stimulation. 3.Time-resolved microscopy, interferometry, and holography of laser-driven transport processes on nanosecond time-scales. Research in the Venugopalan lab involves the integration of experiment, modeling, and computational approaches. Potential students are expected to display a high level of motivation, initiative, and interest in contributing to a dynamic, collaborative, inter-disciplinary research environment. Research Summary : Venugopalan laboratory activities center around the study of photon transport, photo-induced thermal and mechanical transport processes, and their application to non- invasively image, characterize, and/or manipulate biological systems across spatial scales. Our group is highly multi-disciplinary with expertise spanning from applied mathematics, physics, and chemistry on one end to chemical engineering, biomedical engineering, and materials science on the other. Areas of current interest include: 1.Mathematical and computational analysis of light transport in cells and tissues with applications to thick tissue imaging and non-invasive measurement of tissue structure, composition, and function. 2.Development of highly-focused laser microbeam technologies for targeted cellular separation, injection, and mechanical stimulation. 3.Time-resolved microscopy, interferometry, and holography of laser-driven transport processes on nanosecond time-scales. Research in the Venugopalan lab involves the integration of experiment, modeling, and computational approaches. Potential students are expected to display a high level of motivation, initiative, and interest in contributing to a dynamic, collaborative, inter-disciplinary research environment. Vasan Venugopalan Profes sor B.S. (with honors) Mechanical Engineering, University of California, Berkeley (1988) S.M., Sc.D., Mechanical Engineering, Massachusetts Institute of Technology (1990, 1994) Vasan Venugopalan Profes sor B.S. (with honors) Mechanical Engineering, University of California, Berkeley (1988) S.M., Sc.D., Mechanical Engineering, Massachusetts Institute of Technology (1990, 1994) Key Publications: 1.“Impact of release dynamics of laser-irradiated polymer micropallets on the viability of selected adherent cells”, H. Ma, W Mismar, Y Wang, DW Small, M Ras, NL Allbritton, CE Sims, V Venugopalan. Journal of the Royal Society Interface (2012). 2.“Analysis of single Monte Carlo methods for prediction of reflectance from turbid media”, M Martinelli, AR Gardner, DJ Cuccia, CK Hayakawa, J Spanier, V Venugopalan. Optics Express 19(20):19627–19642, (2011). 3.“Amplitude and phase of tightly focused laser beams in turbid media”, CK Hayakawa, V Venugopalan, VV Krishnamachari, EO Potma, Physical Review Letters 103(4):0439039, (2009). 4.“Biophysical response to laser microbeam-induced cell lysis and optoinjection”, Journal of Biophotonics 1(1):24-35, (2008). 5.“Laser-induced mixing in microfluidic channels”, Analytical Chemistry 79(12):4484-4492, (2007). 6.“Laser microbeam induced cell lysis: Time-resolved imaging and analysis of hydrodynamic effects”, Biophysical Journal 91(1):317-329, (2006). Key Publications: 1.“Impact of release dynamics of laser-irradiated polymer micropallets on the viability of selected adherent cells”, H. Ma, W Mismar, Y Wang, DW Small, M Ras, NL Allbritton, CE Sims, V Venugopalan. Journal of the Royal Society Interface (2012). 2.“Analysis of single Monte Carlo methods for prediction of reflectance from turbid media”, M Martinelli, AR Gardner, DJ Cuccia, CK Hayakawa, J Spanier, V Venugopalan. Optics Express 19(20):19627–19642, (2011). 3.“Amplitude and phase of tightly focused laser beams in turbid media”, CK Hayakawa, V Venugopalan, VV Krishnamachari, EO Potma, Physical Review Letters 103(4):0439039, (2009). 4.“Biophysical response to laser microbeam-induced cell lysis and optoinjection”, Journal of Biophotonics 1(1):24-35, (2008). 5.“Laser-induced mixing in microfluidic channels”, Analytical Chemistry 79(12):4484-4492, (2007). 6.“Laser microbeam induced cell lysis: Time-resolved imaging and analysis of hydrodynamic effects”, Biophysical Journal 91(1):317-329, (2006). Focused laser beam propagation in turbid media Laser based for microfluidic mixing and cell lysis Nanosecond laser-microbeam cell lysis