1. Figure 1 Black bars = Small Intestine White Bars = Colon

2. Figure 2

3. Table 1 Group Supplemented Bran (%) Total (n)MaleFemale Group A0743 Group B5440 Group C151697 Group D30844 Total 352114

4. Figure 3 PCA OPLS-DA AB

5. Figure 4 A B

6. Table 2 No.Retention Time (min)m/z ± 0.02Regulation 12.52148.99Up-regulated 27.71189.02Up-regulated 32.54212.95Up-regulated 43.19218.01Up-regulated 52.54218.97Up-regulated 60.92160.07Down-regulated 74.48226.97Down-regulated

7. Table 3 ProteinFold ChangeDirection Serine protease inhibitor A3G4.35↑ Haptoglobin3.35↑ Major urinary protein 23↑ Fibrinogen gamma chain2.83↑ Fibrinogen beta chain2.77↑ Alpha 1 acid glycoprotein 12.44↑ Ig mu chain C region secreted form2.39↑ Ig kappa chain C region2.27↑ Alpha 2 macroglobulin2.05↑ Apolipoprotein A 11.95↑ Serine protease inhibitor A3 K1.92↑ Serum albumin1.82↑ Immunoglobulin J chain1.77↑ Gelsolin1.77↑ Ig gamma 1 chain C region secreted form1.7↑ Serum amyloid P component1.65↑ Alpha 1 antitrypsin 1 41.6↑ Adiponectin1.58↑ Interleukin 1 receptor accessory protein1.57↑ Complement factor H1.52↑ Alpha 1 antitrypsin 1 11.52↑ Kininogen 11.49↑ Complement factor 11.49↑ Fetuin B1.4↑ Angiotensinogen1.38 ↑ Hemopexin1.34↑ Alpha 1 antitrypsin 1 21.3↑ Beta 2 glycoprotein 11.28↑ Apolipoprotein 1 IV1.28↑ Liver carboxylesterase N1.27↑ Murinoglobulin 11.27↑ Afamin1.25↑ Alpha 1 antitrypsin 1 51.2↑ Alpha 2 HS glycoprotein1.14↑ Complement C31.08↑ Serotransferrin1.06↑ Hemoglobin subunit epsilon Y20.25↓ Carboxylesterase 30.22↓