1. SK Kwok, MD Hong Kong Laser Eye Centre, Hong Kong The author has no financial interest in the subject matter of this e-poster ASCRS 2011 San Diego, US ASCRS 2011 San Diego, US Preliminary Clinical Outcomes of a Non- Invasive, Intrastromal Presbyopic Correction in Asian Eyes

2. Background & Study Purpose Study Purpose: To evaluate the preliminary clinical outcomes of INTRACOR intrastromal presbyopic correction in Asian Eyes. ASCRS 2011, SK Kwok The INTRACOR procedure is performed on a femtosecond laser (TECHNOLAS Perfect Vision). The laser forms a series of concentric rings within the stroma which causes a localised change in the biomechanical properties of the stroma. This leads to a central steepening of the cornea. The procedure takes 20 seconds to perform. The procedure uses a curved Patient Interface which adapts to the natural shape of the cornea, without applanation, reducing the increase in IOP when applying suction Note: INTRACOR is not currently approved for use in the US

3. Methods & Materials A prospective, non-comparative case series where the INTRACOR procedure was performed on 128 eyes of Asian patients using the TECHNOLAS Femtosecond Workstation 520F (Technolas Perfect Vision). The non-dominant eye was treated first. Patient Demographics: 79 Females and 49 Males patients Mean Age : 53 years old (range: 41 - 66) 58 OD were treated; 70 OS were treated Pre-operative examinations: Included distance and near vision, corneal, topography, slit lamp examination and patient satisfaction Measured outcomes: Visual acuity (UCNVA, UCDVA, BCDVA), Refractive outcomes, patient satisfaction Post-operative follow-up at 1D, 1W, 1M and 3M ASCRS 2011, SK Kwok TECHNOLAS 520F

4. Results: Slit lamp and topography INTRACOR post-1-week slit lamp INTRACOR Orbscan difference map (post-1-month) Central steepening by 2.50 – 3.00D ASCRS 2011, SK Kwok

5. J1 J2 J4 J10 J6 J1+ -0.08 LogMAR 0 0.1 0.2 0.4 0.7 Results: UCDVA & UCNVA J10 J2 ASCRS 2011, SK Kwok

6. Results: Refractive stability ASCRS 2011, SK Kwok

7. J1 J4 J6 J9 J12 J14 Pre-opn = 128 1Dn = 126 1Wn = 96 1Mn = 68 3Mn = 20 ASCRS 2011, SK Kwok Results: UCNVA (LogMAR)

8. Pre-opn = 128 1Dn = 126 1Wn = 96 1Mn = 68 3Mn = 20 ASCRS 2011, SK Kwok Results: UCDVA (LogMAR)

9. Results: Cumulative UCNVA ASCRS 2011, SK Kwok Pre-opn = 128 1Dn = 126 1Wn = 96 1Mn = 68 3Mn = 20

10. Pre-opn = 128 1Dn = 126 1Wn = 96 1Mn = 68 3Mn = 20 Results: Cumulative BCDVA ASCRS 2011, SK Kwok

11. Results: Patient Satisfaction Some patients could see the rings but their vision is not disturbed. A few patients encountered halos but the symptoms dissipated after one month. Most patients are happy with their enhanced quality of life without reading glasses. ASCRS 2011, SK Kwok

12. Conclusion In my opinion, the intrastromal presbyopia treatment INTRACOR is Non invasive so very low risk for infections Provides stable refractive outcome during the follow up period to-date Provides a significant gain in uncorrected near visual acuity Creates a central steepening and induces about –0.50D to –0.75D of myopia No weakening of cornea High level of patient satisfaction Further long-term follow-up required to confirm stability of outcomes ASCRS 2011, SK Kwok