1. Digital technologies that will bring better care to more people at lower cost Fujitsu Laboratories of America Technology Symposium 5 June 2013 Mark Zdeblick, Ph.D. Co-Founder and CTO

2. 2 ©2012 Proteus Confidential Personal Medical Records Percent of People with Type 2 Diabetes <4% 4% 5% 7% 9% >12% > 99% chance of sending a message within 20 minutes Percent of People with Cell Phone Coverage Source: International Telecommunications Union 2010 Global Rise in Chronic Disease; Global Spread of Mobile Technology

3. 3 ©2012 Proteus Confidential Tablet Computer, Pills and Patch

4. 4 ©2012 Proteus Confidential The Digital Health Feedback System

5. 5 ©2012 Proteus Confidential Tracking Adherence Enables Carer to Identify Patients Who Need Help Missed dose Inconsistent dosing - amount and time Good Adherer A patient who takes pills at the same time everyday. No adherence intervention needed. Poor Adherer A patient who skips pills some days and has inconsistent dosing time. Reminders or other interventions may be beneficial. Heart rate Consistent daily dosing

6. 6 ©2012 Proteus Confidential Tracking Physiology Enables Carers to Identify Problems Early Normal Walking Unstable Walking Healthy Volunteer: Regular Sleep Pattern Neuropsychiatric Patient: Disrupted Sleep Patterns

7. 7 ©2012 Proteus Confidential What is the Ingestible Event Sensor? Active layers Thin-film layers activate and power the IES using stomach electrolytes Active layers Thin-film layers activate and power the IES using stomach electrolytes Edible Skirt disk Insulating edible material, enhances detected voltage by creating a larger “virtual dipole” Edible Skirt disk Insulating edible material, enhances detected voltage by creating a larger “virtual dipole” Communication through body tissue Electric field is detected by a receiver worn on the patient’s skin Communication through body tissue Electric field is detected by a receiver worn on the patient’s skin Integrated Circuit Modulates / pulses the current flow to encode information stored in it Integrated Circuit Modulates / pulses the current flow to encode information stored in it

8. 8 ©2012 Proteus Confidential www.proteusdh.com Thank you!