1. UKHLS Consultation Launch, 19/06/07, RSS Health Outcomes and Health Related Behaviour Scott Weich Dieter Wolke University of Warwick

2. UKHLS Consultation Launch, 19/06/07, RSS Opportunities Address questions at the interface between social science and biomedical research, including gene x environment effects. Longitudinal design, household recruitment and sample size make UKHLS uniquely suited to studying - Transitions across entire lifespan (inc pre-conception) - Effects of household and family - Ethnic differences Chance to study well-being as well as pathology, and to describe & understand causes and consequences of positive health states Linkage to NHS IT networks and routine data sources?

3. UKHLS Consultation Launch, 19/06/07, RSS The importance of studying households: variance in GHQ-12 scores

4. UKHLS Consultation Launch, 19/06/07, RSS Challenges Limited questionnaire space and interview time Respondent fatigue Interviewer training and equipment costs for even basic physical data collection No funding beyond core measures Non-participation in invasive procedures, and particular challenges associated eg with fasting samples Optimum measurement frequency unclear Huge range of potential health measures

5. UKHLS Consultation Launch, 19/06/07, RSS BHPS Measures Disability (defined by receipt of benefits) Health limits housework/stairs/dressing/walking Health limits work Registered as disabled Self-rated health Checklist of 12 + 1 health problems (up to 4) 12-item General Health Questionnaire GP consultations: count Accidents Admissions to hospital Check-ups Smoking

6. UKHLS Consultation Launch, 19/06/07, RSS Core Measures: Initial UKHLS Focus Body composition Importance of describing & understanding recent (and worsening) obesity epidemic; Factors that enable or prevent lifestyle change; Height, weight, waist & hip circumferences Mental health and well-being Globally, depression major cause of DALYs; Major cause of health care seeking in primary care; Major cause of time lost from work; Great interest in epidemiology of (mental) well-being

7. UKHLS Consultation Launch, 19/06/07, RSS Non-Core Measures? Genotyping Cardiovascular health: BP, heart rate, ECG Metabolic health: glucose, lipids, cholesterol (fasting?) Psychosis and Personality Disorder Early indicators of cognitive decline HPA axis and autonomic nervous system markers (endophenotypes) Inflammatory markers