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Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy.

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Presentation on theme: "Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy."— Presentation transcript:

1 Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

2 CSB Fig 02:01 Cell signalling pathways CSB Fig 02:01 Cell signalling pathways Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

3 Transducers Second Messengers II 1.Cyclic ADPribose ADP Ribosyl cyclase ADP Ribosyl cyclase 2.Inositol phosphate & other lipid signaling PLC – PIP2, DAG PLC – PIP2, DAG PI3K – PIP3 PI3K – PIP3 PLD – PA PLD – PA

4 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:22 cADPR metabolism CSB Fig 2:22 cADPR metabolism

5 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:26 NAADP structure CSB Fig 2:26 NAADP structure

6 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:23 cADPR/NAADP function CSB Fig 2:23 cADPR/NAADP function

7 Transducers Second Messengers II 1.Calcium signaling 1.Cyclic ADPribose 2.Inositol phosphate & other lipid signaling PLC – PIP2, DAG PLC – PIP2, DAG PI3K – PIP3 PI3K – PIP3 PLD – PA PLD – PA

8 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:30 Phosphoinositide signalling systems CSB Fig 2:30 Phosphoinositide signalling systems

9 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:27 Phosphoinositide metabolism CSB Fig 2:27 Phosphoinositide metabolism

10 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:28 PtdIns structure CSB Fig 2:28 PtdIns structure

11 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:29 PI 3-K family CSB Fig 2:29 PI 3-K family

12 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:31 Inositol phosphate metabolism CSB Fig 2:31 Inositol phosphate metabolism

13 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:32 InsP3 and DAG formation CSB Fig 2:32 InsP3 and DAG formation

14 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:33 InsP3 and DAG formation CSB Fig 2:33 InsP3 and DAG formation

15 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:34 InsP3/Ca2+ signalling functions CSB Fig 2:34 InsP3/Ca2+ signalling functions

16 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:35 InsP3/DAG recycling CSB Fig 2:35 InsP3/DAG recycling

17 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:36 PLC structure and function CSB Fig 2:36 PLC structure and function

18 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:37 PKC structure and activation CSB Fig 2:37 PKC structure and activation

19 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:38 Localized inositol lipid signalling CSB Fig 2:38 Localized inositol lipid signalling

20 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:39 PtdIns4,5P2 signalling CSB Fig 2:39 PtdIns4,5P2 signalling

21 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:40 PtdIns4,5P2 regulation of K+ channels CSB Fig 2:40 PtdIns4,5P2 regulation of K+ channels

22 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:41 PtdIns4,5P2 regulation of TRP channels CSB Fig 2:41 PtdIns4,5P2 regulation of TRP channels

23 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:42 PtdIns 3-kinase signalling CSB Fig 2:42 PtdIns 3-kinase signalling

24 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:43 Insulin receptor CSB Fig 2:43 Insulin receptor

25 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:44 PIKfyve activation CSB Fig 2:44 PIKfyve activation

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