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Ciprofloxacin Inhibition of Experimental Fracture-Healing* by P. M. HUDDLESTON, J. M. STECKELBERG, A. D. HANSSEN, M. S. ROUSE, M. E. BOLANDER, and R. PATEL.

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Presentation on theme: "Ciprofloxacin Inhibition of Experimental Fracture-Healing* by P. M. HUDDLESTON, J. M. STECKELBERG, A. D. HANSSEN, M. S. ROUSE, M. E. BOLANDER, and R. PATEL."— Presentation transcript:

1 Ciprofloxacin Inhibition of Experimental Fracture-Healing* by P. M. HUDDLESTON, J. M. STECKELBERG, A. D. HANSSEN, M. S. ROUSE, M. E. BOLANDER, and R. PATEL J Bone Joint Surg Am Volume 82(2):161-73 February 1, 2000 ©2000 by The Journal of Bone and Joint Surgery, Inc.

2 Fig. 1-A Histological appearance of the fracture callus from a control rat after four weeks of healing. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

3 Fig. 1-B Histological appearance of the fracture callus from a control rat after four weeks of healing. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

4 Fig. 2-A Histological appearance of the fracture callus from a ciprofloxacin-treated rat after four weeks of healing. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

5 Fig. 2-B Histological appearance of the fracture callus from a ciprofloxacin-treated rat after four weeks of healing. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

6 Fig. 3 High-magnification photomicrographs showing the histological appearance of the endochondral ossification front in calluses from control (A) and ciprofloxacin-treated (B) animals. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

7 Fig. 4 High-magnification photomicrographs showing the morphology of the chondrocytes at the endochondral ossification front in calluses from control (A) and ciprofloxacin-treated (B and C) animals. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

8 Fig. 5 High-magnification photomicrographs showing the trabecular structure at the endochondral ossification front in calluses from control (A) and ciprofloxacin-treated (B and C) animals. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

9 Fig. 6-A Histological appearance of areas of cystic degeneration seen at a distance from the fracture callus in specimens from the ciprofloxacin-treated rats. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

10 Fig. 6-B Histological appearance of areas of cystic degeneration seen at a distance from the fracture callus in specimens from the ciprofloxacin-treated rats. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

11 Fig. 7-A Ultrastructural appearance of chondrocytes and surrounding matrix in the fracture callus of control (Fig. 7-A) and ciprofloxacin-treated (Fig. 7-B) rats after four weeks of healing. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

12 Fig. 7-B Ultrastructural appearance of chondrocytes and surrounding matrix in the fracture callus of control (Fig. 7-A) and ciprofloxacin-treated (Fig. 7-B) rats after four weeks of healing. P. M. HUDDLESTON et al. J Bone Joint Surg Am 2000;82:161-73 ©2000 by The Journal of Bone and Joint Surgery, Inc.

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