1. Bone Physiology Chapter 7 Pages 124-130

2. STRUCTURE: Epiphysis Ends of bones, enlarged for joining with the next bone— proximal and distal

3. Diaphysis Shaft of the bone Periosteum Membrane attached to bone (tendon/ligament attachment)

4. Compact Bone Solid, strong-diaphysis Spongy Bone Branching, resists compression-epiphysis

5. Medullary Cavity Hollow chamber Contains blood vessels and nerves Endosteum Internal lining

6. Marrow Soft connective tissue Produce blood cells

7. MICROSCOPIC: Osteonic Canal Contain blood vessels and nerves Osteocytes arranged in circles around the canal

8. Communication Canals Connect osteonic canals

9. BONE GROWTH: Page 127 Intramembraneous Bones Broad, flat bones of the skull

10. Layers of connective tissue become osteoblasts (bone forming cells) When a matrix surrounds osteoblasts & becomes osteocytes

11. Endochondral Bone Make up most of the bones of the skeleton Mass of cartilage Primary ossification center-diaphysis

12. Secondary ossification center = epiphysis Cartilage between centers form growth plates

13. A lot of mitosis (growth) until ossified, cartilage on ends remain

14. HOMEOSTASIS: Osteoblasts build Osteoclasts dissolve Constantly modify bone

15. Osteocytes are mature bone cells Blood cell formation= Hematopoiesis

16. FUNCTIONS: Support, protection, movement

17. Bone Marrow is found in shaft of long bones, in spaces of spongy bones, and in large osteonic canals of compact bone

18. Red Marrow forms RBCs Yellow Marrow replaces red with age (inactive in blood cell production), aids in fat storage

19. Storage of calcium salts Low calcium- osteoclasts break down bone tissue

20. High calcium-inhibits osteoclasts, osteoblasts are stimulated to form bone tissue