1. Many Brain Regions Are Involved in Processes of Attention Several cortical regions are associated with the source or control of attention. The lateral intraparietal area—or LIP—is involved in the top- down control of attention in monkeys. The human homolog to this region is the intraparietal sulcus (IPS). Both encode a salience map (or priority map) controlling the voluntary shifts of attention. The frontal eye field (FEF) establishes gaze in accordance with cognitive goals (top-down processes) rather than with characteristics of stimuli. The temporoparietal junction (TPJ) helps shift attention to a new location after target onset.

2. Cortical Regions Implicated in the Top-Level Control of Attention

3. A Frontoparietal Attentional Control Network

4. The Cortical Attentional Control Network

5. Diagnostic Test for Hemispatial Neglect

6. Brain Damage in Hemispatial Neglect

7. Three Views of the Human Brain

8. Frontal Lobe 1/3 of all cerebral cortex Primary motor --- Area 4 Premotor --- Area 6 Supplementary motor --- Medial parts of Areas 6, 8 Frontal eye field --- Inferior part of Area 8 Broca’s area --- Areas 44, 45 Prefrontal --- Areas 9, 10, 11, 12, 32 46, 47

9. The Prefrontal Cortex Orbitofrontal Prefrontal Cortex Also named Ventral Prefrontal Cortex (VPFC) Dorsolateral Prefrontal Cortex (DLPFC)

10. Box 18.2 Phineas Gage

11. The Prefrontal Areas Govern Our Most Complex Behavior The prefrontal cortex is the most anterior region of the frontal lobe. Subdivided into Dorsolateral Dorsomedial Ventrolateral (orbitofrontal) Ventromedial (orbitofrontal) The textbook simplifies these subdivisions with just dorsolateral and orbitofrontal regions. Although note that Table 18.2 uses the term Mediofrontal which is the medial part of both dorsal and ventral subdivisions Prefrontal cortex is more prominent in humans and apes than other mammals.

12. Table 18.2 Core Characteristics of the Regional Prefrontal Syndromes

13. Major Functional subdivisions of the human frontal lobes

14. Functions of the Prefrontal Cortex Dorsolateral area functions in intellectual activities such as planning, judgement, problem solving and conceptualizing –Executive Functions Goal Selection The development of an action plan. Sequencing Initiation. Monitoring Outcome. The inhibition of distracting or completion of a complex task. Orbitofrontal area functions in visceral and emotional activities –Behavioral self-regulation –Evaluating hedonic information –Error correction in conjunction with Anterior Cingulate Cortex Frontal Poles Autonoetic Awareness –Self knowledge –Binding together the awareness of oneself as continuous through time

15. The PreFrontal Lobes Govern Our Most Complex Behavior Neuroeconomics studies brain mechanisms active during economic decision making. Two main underlying systems: A valuation system to rank choices on worth and reward A choice system to consider alternatives and make the decision Neuroeconomics research confirms that prefrontal cortex inhibits impulsive decisions, enforcing loss aversion. The prefrontal cortex is also activated when faced with more uncertainty or, with the amygdala, when feeling regret for a costly decision.

16. Consciousness Is the Most Mysterious Property of the Nervous System Awareness of external events –Circuits for perceptual awareness across all sensory modalities –Integration across modalities and mental representation in working memory The default mode network (daydreaming mode) –Circuits that are active when the brain is awake and at rest, and attention is not being directed to external events. –Parts of Temporal, Parietal and Frontal lobes –fMRI maps suggest reliance on the frontoparietal network, as well as medial frontal cortex and cingulate. Subjective Sense of Self –The Frontal Poles (particularly on the right): –Autonoetic consciousness and self awareness –Humor and theory of mind. The PreFrontal Lobes Govern Our Most Complex Behavior

17. Bi-directional connections with almost all parts of the brain so prefrontal cortex can coordinate processing across wide regions of the CNS The human orbitofrontal cortex: linking reward to hedonic experience Morten L. Kringelbach, Nature Reviews Neuroscience 6, 691-702 (September 2005)

18. Table 18.1 Regional Prefrontal Syndromes

19. caused by head trauma, tumours, degenerative diseases, neurosurgery and cerebrovascular disease a set of behaviors commonly encountered in neuropsychiatric patients disinhibition, stimulus-bound behavior, Disorganization social inappropriateness overactivity, apathy, Perseveration no longer useful because it implies damage to a specific region of the brain. The clinical presentations involved reflect dysfunction in several parts of the brain, some of which are in the frontal lobes and some of which are not. Frontal Lobe Disorder “Syndrome”

20. Common post-TBI psychiatric comorbidities include affective, cognitive, and behavioral disorders personality changes commonly seen after TBI : disinhibition, impulsivity, and inadequate self-monitoring of interpersonal behavior. Personality changes associated with TBI can be difficult to differentiate from mania or hypomania Traumatic Brain Injury “TBI”

21. Dysfunctions of Medial and Lateral Orbitofrontal Cortex in Psychopathy Psychopathy: a developmental disorder with two main components: –1. emotional dysfunction reduced guilt reduced empathy reduced attachment to significant –2. predisposition to antisocial behavior from an early age –Psychopathy also has increased risk for both instrumental and reactive aggression instrumental aggression is purposeful and goal directed reactive aggression is triggered by a frustrating or threatening events –strongly heritable component (67% heritability) –Communication between amygdala and medial Orbital Frontal Cortex reduced amygdala responding to emotional words reduced amygdala responses to emotional expressions reduced autonomic responses to the distress cues of other individuals –expressions of fear and sadness serve as social reinforcers

22. Role of the Amygdala –Make emotional judgments based on facial stimuli –Makes it possible to judge complex social emotions Role of the medial OFC –goal-directed instrumental action selection learning of stimulus–outcome associations learning of response–outcome associations –representation of reinforcement information –increased activity to personal as opposed to impersonal moral choices Role of the dorsal anterior cingulate cortex –monitoring and resolution of response conflict Psychopathy response pattern –reduced amygdala responses to the emotional words –reduced rostral anterior cingulate cortex/medial OFC activation Dysfunctions of Medial and Lateral Orbitofrontal Cortex in Psychopathy

23. The Unconscious Brain

24. Dimensions of Consciousness

25. Easy and Hard Problems of Consciousness

26. Act First, Think Later