1. LS Services Portfolio

2. Definitions Services – For the purpose of this exercise services are capabilities that we can conceive reusing in a number of applications, or for which NCI needs to be authoritative – Functional Profiles – groups of operations that conform to usage patterns (administration, query, management, publish) to support a responsibility (as defined by the community) – Proposed Operations – high level, maybe even abstract, expressions of actions that can support the responsibility

3. Service Taxonomy Taxonomy Level Functional ProfileOperationNotes Process Aligns with transactional capability Generally very fine grained, few operations per profile Expedia or Travlocity, Register Subject for Trial … Capability Aligns with domain objects and their states Administrative, Management, Query Specimen Management Core / Entity Aligns with Information Objects, states are for integrity Management, QueryAllergy, Agent, Drug Infrastructure Technology-specific that supports business needs, not aligned with a single line of business VariableEmail, Notification, Translation, Transformation Utility Utility functions that align with business well VariableIdentification, DeIdentification,

4. BIG Health Enterprise Service Portfolio NCI Clinical Trials Reporting Program ca- AERS PSCC3PRC3D caBIG ® Clinical Trials Suite caGrid R Registration Ae Adverse Event Pt Protocol caTissuecaEHR “B USINESS ” “ C ORE ” PLTFirebird “C APABILITY ” S Specimen Sc Scheduling Tx Translation Au Audit Ra Referral and Authorization Hx Hx and Physical Va Validation Ev Enterprise Vocabulary O Organization P Person A Agent D Disease C Correlation Pa Protocol Abstraction Dn Discharge Note Cq Clinical Research Qry Tp Treatment Plan Ds Decision Support I Image L Lab Rx Prescription “Infra / U TILITY ” Cm Contract Management Mp Master Problem List Ay Allergy Sd SDTM E Eligibility Km Knowledge Management Cr Credentialing Oc Study Outcomes Qr Data Query Id Management Tr Trust Management Aa Authorization Authentication Py Policy Oo Orders Observations

5. LS Portfolio … First Cut Array Services Molecular Services Specimen Services Biological Model Services Nanoparticle Services Population Study Services Study Design Services Data Analysis Services Pathway Modeling Services 3D Modeling Manipulation Services Analysis Pipeline Services

6. ProfileOperationDescription Microarray Experiment Capability QueryQuery by ExampleRetrieve Experiments that match an example Query by CriteriaRetrieve Experiments that match specified criteria Query By KeywordRetrieve Experiments that match a given keyword Retrieve By IdRetrieve Experiment with given identifier ManagementCreate ExperimentCreate a new experiment with given information Update ExperimentUpdates an experiment with new information Remove ExperimentRemoves an experiment from the repository Add BiomaterialsAssociate a Biomaterial with an experiment Remove BiomaterialsDissociate a Biomaterial from an experiment Security Set Permissions for ExperimentSpecify access levels to experiment for groups of users Data ManagementAdd DataAssociates data files with an experiment Import DataImport array data in files associated with an experiment Validate DataValidate whether files contain valid data Data RetrievalRetrieve Data SetRetrieve parsed data set associated with this experiment Export as MAGE-TABExport experiment annotation and data as a mage-tab data set Export as GEOExport experiment annotation and data as a data set for import to GEO Workflow Update Experiment StatusUpdates the workflow status of an experiment Lock ExperimentLocks the experiment from further changes Unlock ExperimentLocks the experiment from further changes

7. Services Architecture and Implementation Specification Domain Analysis (Communities, Concepts, and Rules) Information Model Behavioral Model Deployment Model Technology Model Implementers may take specifications, components, reference implementations, or parts of all three to achieve working interoperability Component Service Implementation Service Metadata in deployment [jurisdiction, provenance, description, etc.]

8. BAM / DAM / Service Specifications App / Tool / Suite Implementation Service Implementation Clinical / Study workflow Bench Research Domain Clinical Research Domain Integrated Clinical & Translational Domain Study PlanStudy Set UpStudy ConductStudy Analyze & Report Manage StudyManage SubjectsManage Data Quantify CRA Workload Re-consenting Subjects Enroll Subjects AE Triggered mod Identify Potential dose change Load Lab data Data for Interim Analysis … Decomposing the TCM: A High Level road map of the Transcend project

9. Infrastructure Resolution Interoperability (2.1G) (For Example, Transcend v 2) NCI Research Lab Exposed Capabilities (Services) Internal Capabilities (Services) Researcher caEHR Semantic Security Technology

10. Interoperability (3.1G) Big Health NCI Onc EHR Research Lab Lab Exposed Capabilities (Services) Internal Capabilities (Services) Researcher ??? Technology Stacks