1. UK e-Science 2008 All Hands Meeting. Edinburgh. Data Sharing e-Infrastructure David Rodriguez 1, Trevor Carpenter 2, Jano van Hemert 1 & Joanna Wardlaw 2. On behalf of the SINAPSE Collaboration. 1. National e-Science Centre. School of Informatics, University of Edinburgh. 2. SFC Brain Imaging Research Centre. Department of Clinical Neurosciences, University of Edinburgh.

2. UK e-Science 2008 All Hands Meeting. Edinburgh. Contents  The SINAPSE project  Data Protection & pseudonymisation  Data sharing  Components  Status

3. UK e-Science 2008 All Hands Meeting. Edinburgh. Contents  The SINAPSE project  Data Protection & pseudonymisation  Data sharing  Components  Status

4. UK e-Science 2008 All Hands Meeting. Edinburgh. The SINAPSE Project  Stands for Scottish Imaging Network: a Platform for Scientific Excellence.  Pooling initiative of six Scottish universities: Aberdeen, Dundee, Edinburgh, Glasgow, St. Andrews and Stirling.  Main objectives: develop imaging expertise, support multi-centre clinical research in conjunction with the Clinical Research Networks, improve the ability of neuroscientists to collaborate on clinical trials, have a direct impact on patient health.

5. UK e-Science 2008 All Hands Meeting. Edinburgh. Data Sharing e-Infrastructure  For enabling multi-centre clinical research through data sharing.  The main objectives of the SINAPSE e- infrastructure project are: Anonymisation, automatic compliance with data protection policies; Security, advanced authentication and authorisation within projects; Usability, providing a user friendly environment to access data and applications; Modularity, conforming to relevant standards and use of existing components; Centralisation, leveraging existing compute clusters and storage.

6. UK e-Science 2008 All Hands Meeting. Edinburgh. Benefits  Easier Data Protection compliance for users  Enables secure data sharing  Coherent view of available data (single point of access)  Roadmap for end-of-project data publication & data curation

7. UK e-Science 2008 All Hands Meeting. Edinburgh. Key Features  Single sign-on: identify once per session for all the services. Delegated authentication to home universities  Permission management using groups and roles  Data Catalogue: Files Catalogue Metadata Catalogue: storing relevant information to allow users find the desired data  Modularity Reuse existing components Allows future updates/changes

8. UK e-Science 2008 All Hands Meeting. Edinburgh. Access Levels  Different access levels for different users/use cases  From only file access to encrypted files for site operators  Researchers sometimes just need access to decrypted images and associated basic image metadata, other will access to more clinical information and metadata.

9. UK e-Science 2008 All Hands Meeting. Edinburgh. Contents  The SINAPSE project  Data Protection & pseudonymisation  Data sharing  Components  Status

10. UK e-Science 2008 All Hands Meeting. Edinburgh. Data Protection  Data Protection Act (1998). Other legislation applies. Personal data must be processed in a fair and lawful manner. Projects to be run in SINAPSE shall have a proper consent form for the processing to be done. All ethical approval.  Pseudonymous identifier to substitute the CHI (Community Health Index). Linked using a database.  Anonymisation of other fields. Full destruction of the information for some data like name or address. Depending on the project some might be transformed into less informative representations:  Postal Code -> Deprivation Index or partial Postal Code  Date of birth -> Age (with different precisions).  Any later access to personal data will be granted by the corresponding Data Controller. All personal data processing will be logged for auditing.

11. UK e-Science 2008 All Hands Meeting. Edinburgh. Data Pseudonymisation National PACS CHI Transformation Service Pseudonymisation Application Local Storage Anonymous research data Link Table NHSResearch Centre

12. UK e-Science 2008 All Hands Meeting. Edinburgh. Pseudonymisation Tool  Implemented in Java.  To be deployed as near as possible to the data acquisition. Can be configured for each site.  Configurable using XML documents. Different projects can apply different policies. The policy specifies the classes that will execute the transformation of the data. Graphical tool for editing the policies.  These classes will be distributed in signed jars, and their authenticity will be checked using their hash. For data provenance checks and auditing purposes the classes’ version will be tracked.

13. UK e-Science 2008 All Hands Meeting. Edinburgh. CHI Transformation Service  CHI (Community Health Index) is the National unique identifier for NHS (Scotland) patients Used in any health related communication As it identifies the patient it is sensitive information  It is composed of 10 digits that include Date of birth Gender Control digit  Possibilities Reversible / Irreversible transformation Unique for all Sinapse / Unique for each Data Controller

14. UK e-Science 2008 All Hands Meeting. Edinburgh. Contents  The SINAPSE project  Data Protection & pseudonymisation  Data sharing  Components  Status

15. UK e-Science 2008 All Hands Meeting. Edinburgh. Data Sharing  Centralised model adopted: cheaper, easier, allows to reduce the IT burden undertaken by research staff. Although there are several grid projects that provide DICOM functionalities.  The research data will be encrypted before storing it.  Data organised per project Access control using groups & roles.  Authentication using Shibboleth due to usability concerns regarding X.509 certificates.

16. UK e-Science 2008 All Hands Meeting. Edinburgh. Data Files University Authentication Service VOMS Metadata Catalogue SINAPSE Storage Data Catalogue Uploading Data Local Storage Portal Data Upload Service Metadata extraction Data Encryption Data Storage

17. UK e-Science 2008 All Hands Meeting. Edinburgh. Centralised Architecture  Simpler Deployment  Easier middleware release control  Lesser impact in participant centres  Easier to manage and use  No default resilience A second centre would be needed But this is only necessary for critical services With a good support a reasonable service can be provided using a single centre

18. UK e-Science 2008 All Hands Meeting. Edinburgh. Deployment Plan  ECDF (http://www.is.ed.ac.uk/ecdf/) ‏http://www.is.ed.ac.uk/ecdf/ A singular facility along Scotland  Disk space and CPU time will be rented depending on the necessities. 1456 CPU cores 275 TB of disk  Also SINAPSE owned server to be hosted by ECDF: ECDF will provide basic hardware + software support SINAPSE services to be hosted in it:  Portal  Data Catalogue  Research Data encryption service  OGSA-DAI  Projects’ customised databases  RAPID…

19. UK e-Science 2008 All Hands Meeting. Edinburgh. Advantages  Cheaper start up and running costs without loss of performance compared to the alternatives presented. Small initial deployment Cost fully transparent, no need to factor in costs for cooling, power, insurance, backups, off-site backups and staff training Massively reduced depreciation on investment An easy way to scale up to meet increases in demand Flexibility for future development  24 hours, 7 days a week service availability with 9am to 5pm systems support by experts. Operating system, Hardware and Storage maintained and upgraded by ECDF staff No increase in system administration workload for the participant centres No need to open firewalls to deliver new services in participating centres

20. UK e-Science 2008 All Hands Meeting. Edinburgh. Contents  The SINAPSE project  Data Protection & pseudonymisation  Data sharing  Components  Status

21. Components

22. UK e-Science 2008 All Hands Meeting. Edinburgh. Portal  A gridsphere based portal will give access to the resources.  Basic functionality to be provided by SINAPSE Data uploading Catalogues querying …  The projects will customise the portal for their needs providing their own portlets.

23. UK e-Science 2008 All Hands Meeting. Edinburgh. Authentication  Shibboleth federated authentication Single sign-on. Delegated to home universities. Users will continue using a method they are already familiar with.  X.509 certificates are usual in Grids But can be a handicap for some users.

24. UK e-Science 2008 All Hands Meeting. Edinburgh. Authorization  Dynamic Virtual Organisations Members should be added/removed easily New VOs creation for new projects/studies VO role management  Role based access Allows different access levels to information for different users

25. UK e-Science 2008 All Hands Meeting. Edinburgh. Communications  Encrypted communications for all the services: GridFTP SSH HTTPS for web services

26. UK e-Science 2008 All Hands Meeting. Edinburgh. Images Encryption  These keys are to protect research data, not personal data Not so sensitive.  Keys accessible from all the SINAPSE sites  Access to the keys based on groups and roles Project/study dependent

27. UK e-Science 2008 All Hands Meeting. Edinburgh. Catalogues  Data Catalogue for keeping track of the files in the system  Metadata Catalogue storing key attributes extracted from the DICOM headers.  Clinical Information databases and additional metadata databases can be deployed by the different projects.  OGSA-DAI will be used to provide access to this resources.

28. UK e-Science 2008 All Hands Meeting. Edinburgh. Contents  The SINAPSE project  Data Protection & pseudonymisation  Data sharing  Components  Status

29. UK e-Science 2008 All Hands Meeting. Edinburgh. Status  Proposal endorsed by the SINAPSE IT & Image Analysis committee last July.  Grant application for machines & storage resources to be sent soon.  Pseudonymisation tool being tested.

30. UK e-Science 2008 All Hands Meeting. Edinburgh. Questions