1. PREVALENCE OF ORTHOSTATIC HYPERTENSION AND ITS ASSOCIATION WITH METABOLIC AND ECHOCARDIOGRAPHIC PARAMETERS IN ELDERLY PATIENTS WITH TYPE 2 DIABETES INTRODUCTION Cardiovascular autonomic neuropathy is associated with significant morbidity and mortality in patients with type 2 diabetes (T2D) with orthostatic hypotension being the most dangerous complication. Orthostatic hypertention (OHT) has been reported to occur, but studies assessing its effects on health outcomes especially in elderly and diabetics are scarce. The definition, prevalence and its effect on cardiovascular safety is still controversial. Mean duration of diabetes was 12,23 yr (±8,34) and HbA1C was 7,9% (±1,71). The prevalence of OHT was 20,6%. Mean BMI was significantly higher in pacients with OHT in comparation with those without it (29.80 ±4.10 vs. 27.51 ±3.98kg/m 2, p=0.026) as was hip circumference (106.00 ±13.16 vs. 100.59 ±8.56cm, p=0.029). There were no statisticaly significant difference between the two groups in other metabolic paramethers such as waist circumference, serum trigliceryde, HDL-c and HbA1C. CONCLUSION Our data sugests some protective cardiac effect of postural increases in blood pressure in long standing T2D. REFERENCES METHODS An analytic cross-sectional study in 97 diabetic patients aged > 60 yr (mean 68,97 +- 6,80 yr), normotensive or hypertensive on angiotensin converting enzyme inhibitors, angiotensin receptor blockers or calcium channel blockers only. OHT was defined as a ≥ 10mmHg increase in systolic blood pressure after 4 minutes in standing against the sitting position Patrícia Mesquita; Deborah Queiroz; Juliana Maia; Manoel Soares Filho; Jéssica Garcia; Alexsandro da Silva; Ana Claudia Torquato; Francisco Bandeira. Division of Endocrinology, Diabetes and Bone Disease, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil www.ued-ham.org.br SUN-810 RESULTS OBJECTIVE The aim of the present study was to determine the prevalence of OHT in enderly patients with type 2 diabetes and its association with metabolic factors, echocardiographic parameters, and chronic complications. Among the 68 patients who did an echocardiographicy examination 27% from those who had OHT had increases in index left atrial volume (iLAV) in comparation with 75% of those who did not have OHT (p=0,004). The average iLAV of patients with OHT was significantly lower in comparation to those without OHT (26.27 ±6.37 vs. 32.65 ±7.54 respectively, p=0.011). 1- Robertson D. Orthostatic Hypertension: The Last Hemodynamic Frontier. Hypertension. 2011;57:158-159. 2- Yoshinari M, Wakisaka M, Nakamura U, Yoshioka M, Uchizono Y, Iwase M. Orthostatic hypertension in patients with type 2 diabetes. Diabetes Care 2001 Oct; 24: 1783 – 1786. 3 - Aurigemma GP, Gottdiener JS, Arnold AM, Chinali M. Left Atrial Volume and Geometry in Healthy Aging The Cardiovascular Health Study. Circ Cardiovasc Imaging. 2009;2:282-289. Table 1 - Clinical and Echocardiografic Characteristcs (n=97) VariableMean Age (years)68,97 ± 6,80 · Gender Male30,9% Female69,1% Diabetes Duration (years)12,23 ± 8,34 BMI (kg/m2)27,95 ± 4,06 Waist Circumference (cm) 98,45 ± 12,43 Hip Cimcumference (cm)101,71 ± 9,85 Left Atrial Volume (ml/m 2 )121,77 ± 22,81 Left ventricular mass index (g/m 2 )31,60 ± 7,64 Orthostatic Hypotension (DPAS > 20 and/or DPAD > 10mmHg) 3,1% Orthostatic Hypertension (DPAS ≥ 10mmHg) 20,6% Table 2 - LAB DATA Fasting Glucose143,20 ± 56,41 HbA1C (%)7,90 ± 1,71 MDRD (ml/min/1,73m 2 )91,85 ± 25,98 HDL (mg/dL)52,91 ± 22,73 LDL (mg/dL)97,95 ± 31,95 Triglycerides(mg/dL)136,61 ± 58,75 Table 3- Medications and Comorbidities Medications % Statin60,8 ACE inhibitor49,5 ARB23,7 CCB19,6 Aspirin52,6 Metformin76,3 Sulfonylurea 32 Insulin34 Comorbities Hypertension79,4 Stroke4,1 Myocardial Infarction3,1 CABG2,1 PVD1 Graphic 1 – Increased iLAV in Ecocardiographic Examination ACE: Angiotensin converting enzyme ARB: Angiotensin II receptor blockers CCB: Calcium chanel blockers CABG: Coronary artery bypass grafting PVD: Peripheral vascular disease