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Neuropsychology and differential diagnosis Julie Snowden Cerebral Function Unit Greater Manchester Neuroscience Centre Neuropsychology of Dementia Harrogate, July 2008
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Cortical Subcortical Cortico- subcortical Alzheimer’s disease Frontotemporal dementia Huntington’s disease Progressive supranuclear palsy Subcortical vascular disease Dementia with Lewy bodies Corticobasal degeneration
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MRI coronals SPECT coronal AD sagittal
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FTD MRI coronals SPECT coronal sagittal
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Alzheimer’s disease disorder of cognition Impaired memory Impaired word retrieval Spatial disorientation Social preservation Frontotemporal dementia disorder of behaviour Personality change Breakdown social conduct Impaired judgement ‘Instrumental’ skills relatively preserved
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Parietal Temporal Occipital Frontal Praxis Spatial orientation (mental map) Visual perception Language Executive functions Social cognition Episodic memory (events) Alzheimer’s disease (AD) Frontotemporal dementia (FTD)
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AD Cognition Memory –Repetitive in conversation –Gets lost –Mislays objects –Forgets day to day events –Loses track Consistent impairment Cueing limited benefit Loss over delay Reduced immediate span
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Language Hesitant, halting Impaired word retrieval Paraphasic errors (typically infrequent) Loses train of thought/sentences unfinished Reduced span
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Visual Object and Space Perception Warrington & James 1991 Perceptual errors on object naming tests “spectacles” Perception “a T”
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Spatial Impairment lost in familiar surroundings driving accidents difficulty with daily activities: e.g. dressing, stairs VOSP battery Warrington & James, 1991
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Constructional difficulties in Alzheimer’s disease
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Frontotemporal dementia Breakdown in social, interpersonal conduct Neglect of self-care and responsibilities Emotional blunting, loss of insight Repetitive, stereotyped behaviours Hyperorality, dietary changes
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Plans/Goals Organisation Attention Abstraction New plan Checking Flexibility
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Planning Organisation Attention Abstraction Checking Flexibility Inertia/purposeless overactivity Disorganised behaviour Inattentive, distractible, poor persistence Concreteness of thought Poor self-monitoring, impaired insight Inflexible Frontotemporal dementia: Cognition and the frontal lobes
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Wisconsin Card Sorting Test
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Weigls blocks shape, colour, motif Perseverative Dismantling behaviour
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1 2 67 8 910 345 Brixton spatial anticipation test Burgess & Shallice, 1997
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Picture sequencing Impaired executive skills Animals “Billy the budgie and Spot the dog” F words “Frank – my brother” Verbal fluency Concrete, rule violations
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Design fluency in FTD Perseveration, concreteness, rule violation
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FTDAD
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FTD Rapid response Can localise dots AD Slow response Poor localisation
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Cognition in AD and FTD ADFTD LanguageHesitant, impaired word retrieval, paraphasic, loses track Economical, concrete echolalia, stereotypy perseveration Perceptuo- spatial/ construction Loss of spatial configuration Preserved spatial configuration Organisational failures Perseveration
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Cognition in AD and FTD cont. ADFTD Memory Pervasive, consistent Cueing modest benefit Loss over delay Inefficient, inconsistent Benefits from cues No rapid forgetting Executive skills “Can’t do” Overloaded Stuck in set Perseveration Concreteness Rule violations Behaviour Appropriate, concern for accuracy Impulsivity, inattention, poor persistence, economy of effort, unconstrained by goal
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“Subcortical” dementia Mental slowing Poor generation, organisation and sequencing of information Inefficient memory encoding and retrieval No aphasia, agnosia, apraxia No gross personality change
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Paired-associate learning friend – train gold - sugar
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Paired-associate learning uncued % correct
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Paired-associate learning uncued and cued
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Dementia with Lewy bodies Fluctuating mental state Formed visual hallucinations Parkinsonism AD-like cognitive change But: Fluctuations, incoherence, distractibility, intrusions, confabulation, perseveration Misperceptions (Capgras phenomena)
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VOSP screening: errors ***
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Prevalence of interference effects in Azheimer’s disease and dementia with Lewy bodies ** ** *
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Conclusions Dementia not generalised impairment of intellect – constellation of deficits Distinct patterns reflect distribution of pathology Differentiation of forms of dementia possible on neuropsychological grounds Need to take account of qualitative features Important for treatment and management
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