1. COUNTRY COORDINATORS: GUIDO BERTOLINI (IT) - COORDINATOR AKOS CSOMOS (HU) RAFAEL KAPS (SI) THEODOROS KYPRIANOU (CY) ISAAC LAZAAR (IL) MALGOSIA MIKASZEWSKA (PL) NEKTARIA XIROUCHAKI (GR) FUNDING AGENCY: EUROPEAN COMMISSION CREACTIVE Collaborative REsearch on ACute Traumatic brain Injury (TBI) in intensiVe care medicine in Europe

2. Start dateOctober 1 st, 2013 End dateSeptember 30 th, 2018 Project duration60 months CoordinatorGiViTI (Italy) Number of partners9 Number of countries7 Total budget€ 7,032,384 EU contribution€ 5,443,350 CREACTIVE

3. What are key accomplishments in the past 9 months? Web-based system for project management (center registration, monitoring system, translation manager) CRF definition and implementation SOP to collect and storage biological samples SOP to collect and storage imaging, and software alpha-version Telephone-based follow-up protocol, and first-stage training course Authorization of the EC of the participating centers Start the data collection on 15 th March!

4. Expected ICUs ICUsAdmissionsPedsTBITBI peds %TBI CY12270 32017% GR10313 012092% HU102230 1031613% IL51130 12413 10% IT80757270 318547298% PL150- ---- SI54386 4 520 13% TOT126878299459675498% Data collection from March 15 th to June 24 th

5. Expected ICUs ICUsAdmissionsPedsTBITBI peds %TBI CY12270 32017% GR10313 012092% HU102230 1031613% IL51130 12413 10% IT80757270 318547298% PL150- ---- SI54386 4 520 13% TOT126878299459675498% Data collection from March 15 th to June 24 th Projections at the end of the study 9,000 patients 8,300 adults 700 children

6. What are the major challenges or issues, if any? All the project steps are major challenges … … however, we are particularly worry about: Compliance to the 6-month follow-up Protocol for ambulatory follow-up Feed the centers back with useful analyses on their own performance and the ways to improve Comparison among different countries/regions

7. What percentage of your data is comprised of the International TBI Common Data Elements and what percentage are unique data elements? All of the Core CDE, but: - Loss of consciousness - Post traumatic amnesia - modified: race category, ethnicity, education, employment About 1/3 of Basic CDE