1. 1 ASSOCIATION OF INDEPENDENT RESEARCH INSTITUTES PRESENTATION San Antonio Texas September 24 – 26, 2007

2. 2 FY 2008 PRESIDENT’S BUDGET REQUEST TOTAL NIH BUDGET AUTHORITY $28.850 BILLION Research Project Grants 52.0% $15,165 Billion Training 3.0% $761 Million

3. 3 CHANGE IN NIH APPROPRIATIONS FY 1995 - 2008

4. 4 NIH RESEARCH GRANTS FISCAL YEARS 1950 – 2006 Constant dollars based on BRDPI FY 1950 = 100.0 FY 2006 =1216.6

5. 5 NIH EXTRAMURAL AWARDS BY ACTIVITY FISCAL YEARS 1996 and 2006 FY 1996 $9.8 Billion FY 2006 $23.2 Billion

6. 6 NIH SUPPORT TO AIRI MEMBERS PERCENT OF TOTAL EXTRAMURAL

7. 7 NIH EXTRAMURAL AWARDS BY KIND OF INSTITUTION FY 1996, 2001 and 2006 Millions

8. 8 EFFECTS OF INFLATION ON NIH AWARDS TO AIRI MEMBERS Constant Dollars based on BRDPI FY 1996 = 100.0, FY 2006 = 141.5

9. 9 NIH EXTRAMURAL AWARD TO AIRI MEMBERS Fiscal Years 1996 and 2006 FY 2006 $1,527 Million FY 1996 $571 Million

10. 10 NIH EXTRAMURAL SUPPORT TO AIRI MEMBERS BY GRANT ACTIVITY

11. 11 NIH AWARDS TO AIRI MEMBERS BY SUPPORTING INSTITUTE FY 2006 Total Support to Members - $1,526,747,972 NIAID $ 363,541,090NEI $ 35,612,026ORWH $ 8,079,658 NCI $ 357,561,457NHGRI $ 34,085,694NIBIB $ 3,659,624 NHLBI $ 150,338,671NINH $ 31,424,115OD $ 2,589,825 NIGMS $ 129,450,195NIAMS $ 25,972,686NINR $ 2,026,805 NIDDK $ 79,229,398NIDA $ 21,717,846NCCAM $ 1,650,934 NCRR $ 57,144,523NIDCD $ 20,062,268NLM $ 1,249,369 NINDS $ 56,845,513NIAAA $ 19,285,629FIC $ 898,059 NICHD $ 52,613,122NIDCR $ 14,797,900NCMHD $ 534,713 NIA $ 43,779,192NIEHS $ 12,597,660

12. 12 AIRI Members accounted for 6.6% of NIH extramural funding ORWH90.6% NHLBI5.9% NIDA2.7% NIAID10.4% NIAAA5.9% NIEHS2.5% NCI9.9% NICHD5.3% NINR1.7% NHGRI8.6% NIDCR5.2% NCCAM1.6% OD7.6% NIDDK5.1% NIBIB1.3% NIGMS7.0% NIA5.0% FIC1.3% NEI6.5% NCRR4.8% NLM0.4% NIDCD6.3% NINDS4.3% NCMHD0.4% NIAMS6.2% NIMH2.8% PERCENT OF I/C EXTRAMURAL FUNDING AWARDED TO AIRI MEMBERS FY 2006

13. 13 NIH TRAINING AND CAREER AWARDS TO AIRI MEMBERS Fiscal Years 1996, 1999, 2002, 2005, 2006

14. 14 NIH R01 EQUIVALENT (R01, R29 AND R37) COMPETING APPLICATIONS BY FISCAL YEAR OF REVIEW

15. 15 SUCCESS RATES FOR NIH COMPETING R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS

16. 16 SUCCESS RATES FOR NIH COMPETING R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS

17. 17 PERCENT OF R01 EQUIVALENT (R01, R29 AND R37) PROJECTS EVENTUALLY FUNDED BASED ON IRG ACTION OF ORIGINAL (NON-AMENDMENT)

18. 18 NIH COMPETING R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS BY YEAR OF REVIEW

19. 19 SUCCESS RATES OF NIH COMPETING R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS

20. 20 NIH R01 EQUIVALENT (R01, R29 AND R37) RESEARCH PROJECT APPLICATIONS FROM AIRI MEMBERS

21. 21 NIH R01 EQUIVALENT (R01, R29 AND R37) AWARDS FY 2006 Average Budgeted Direct Cost

22. 22 NIH R01 EQUIVALENT (R01, R29 and R37) AWARDS AVERAGE TOTAL COST All Institutions AIRI Members FY NumberCurrent Dollars Constant Dollars NumberCurrent Dollars Constant Dollars 199622190 $ 224,824 1161 $ 270,825 199723054 $ 233,797 $ 227,4691249 $ 279,574 $ 272,008 199824205 $ 243,686 $ 229,3151333 $ 288,122 $ 271,131 199925584 $ 259,077 $ 236,3171425 $ 306,747 $ 279,799 200026860 $ 279,471 $ 245,7611517 $ 326,801 $ 287,382 200127908 $ 300,657 $ 255,8851579 $ 351,234 $ 298,929 200228781 $ 320,012 $ 263,6251607 $ 370,959 $ 305,595 200329527 $ 337,324 $ 268,4501708 $ 394,056 $ 313,599 200429857 $ 348,880 $ 267,6741758 $ 402,518 $ 308,827 200529464 $ 358,757 $ 264,9451785 $ 411,378 $ 303,806 200629039 $ 358,247 $ 253,1851746 $ 414,440 $ 292,898 BRDPI Factor: FY 1996 = 100.0, FY 2006 = 141.5

23. 23 INDIRECT COST (F&A) AS A PERCENT OF TOTAL COST NIH Research Grants - Excludes awards with limited F&A reimbursement, foreign and federal institutions

24. 24 TOTAL AWARDS RECEIVED BY AIRI MEMBERS 19961999200420052006 2122Fred Hutchinson Cancer Research Center $ 251,416,555 1211Scripps Research Institute $ 214,321,359 3333Dana-Farber Cancer Institute $ 128,419,388 9844Gamble Program for Clinical Research at CHRF $ 83,984,690 10965Burnham Institute for Medical Research $ 66,235,933 7657The Jackson Laboratory $ 50,710,040 4576Salk Institute for Biological Studies $ 50,029,464 57911Fox Chase Cancer Center $ 36,992,516 4212108Northern California Institute for Research and Education $ 35,385,432 11 1213The CBR Institute for Biomedical Research, Inc. $ 32,102,419 Ranks based on Total NIH Extramural Support Received

25. 25 NUMBER OF FIRST TIME R01 EQUIVALENT (R01, R29 AND R37) AWARDEES

26. 26 AVERAGE AGE OF COMPETING R01 EQUIVALENT (R01, R29 AND R37) AWARDEES

27. 27 AGE OF COMPETING R01 EQUIVALENT (R01, R29 AND R37) AWARDEES

28. 28 AGE OF COMPETING R01 EQUIVALENT (R01, R29 AND R37) AWARDEES - AIRI

29. 29 Average Age at Time of First Assistant Professorship at US Medical Schools

30. 30 SUCCESS RATES OF R01 EQUIVALENT (R01, R29 AND R37) APPLICATIONS BY TYPE AND AGE OF APPLICANT

31. 31 IN SUMMARY  The NIH budget increased a modest amount (2.4%) from FY 2006 to 2007  The period of doubling (FY 1998 - 2003) has ended!  Research project grants continue to make up the bulk of NIH awards (64%)  AIRI members received over $1.5 billion in NIH awards in FY 2006  RPG's account for over 3/4 of NIH support to AIRI members  NIAID is the largest source of awards to AIRI members, while the Office of Research on Women's Health devotes the largest percent of their budget to AIRI.  Research Career Awards have become the largest source of training/career development support to AIRI members  The number of original, unamended R01 equivalent applications has continued to fall  Projects where the original was unscored have a much lower chance of eventual funding than scored originals  Success rates again fell in FY 2006. AIRI members continued to do better than the NIH average  The average size of awards to AIRI members is nearly 16% higher than the overall NIH average, largely due to higher AIRI F&A rates  Fred Hutchinson Cancer Research Center is the largest recipient of NIH support among AIRI members in FY 2006  In FY 2006, 74 members of AIRI received NIH support  Number of first time investigators is relatively stable across years  The average age of principal investigators is continuing to climb, reaching 52 in FY 2005, matched by increasing age of first assistant professorship at medical schools  Investigators 35 years or younger account for 3 percent of NIH competing R01 equivalent awards  Success rates for new applications fall with increasing age of principal investigators  A different source of information for R&D contracts was used in FY 2006,and data are not final

32. 32 RESOURCES NIH’S AWARD INFORMATION & DATA PAGE AWARD DATA FOR INDIVIDUAL ORGANIZATIONS AGGREGATE DATA http://grants.nih.gov/grants/award/trends/AggregateData.cfm http://grants.nih.gov/grants/award/award.htm

33. 33 THANK YOU