1. NIH PCKD/Emory University MRI Imaging Report 1/31/2000

2. Overview 2 Patients Scanned with NIH Protocol Both: Comparison with “Old Protocol” –Visual comparison –No SNR measurements performed No Breathhold Flow Quantification (Yet) –Philips scanner should be capable –Little experience; Validation experiments?

3. T2-Weighted Multi-Slice (#1) Old Protocol (3 mm) Multiple Breathholds NIH Protocol (5 mm) Single Breathhold

4. T2-Weighted Multi-Slice (#2) Old Protocol (3 mm) Multiple Breathholds NIH Protocol (5 mm) Single Breathhold

5. T2-Weighted Imaging: Remarks 3 mm slice thickness resolves cysts better Fat Suppression useful, works well Multiple-breathhold: registration needed –Kidney “rigid object”: overlap + affine Xform –Avoid misregistration between interlaced stacks Role in image analysis?

6. T1-Weighted 3-D (PRE-#1) Old Protocol (2.5/5 mm)  =40  Single Breathhold NIH Protocol (2.5/5 mm)  =12  Single Breathhold

7. Weighted T1-Weighted 3-D (PRE-#2) Old Protocol (2.5/5 mm)  =40  Single Breathhold NIH Protocol (2.5/5 mm)  =12  Single Breathhold

8. Weighted T1-Weighted 3-D (POST-#1) Old Protocol (2.5/5 mm)  =40  90 s post-Gado NIH Protocol (2.5/5 mm)  =12  120 s post-Gado

9. T1-Weighted 3-D (POST-#2) Old Protocol (2.5/5 mm)  =40  60 s post-Gado NIH Protocol (2.5/5 mm)  =12  120 s post-Gado

10. T1-Weighted 3-D Ghost artifact due to heart motion (?) Apply pre-saturation slab anterior to volume to reduce intensity? heart liver

11. T1-Weighted Imaging: Remarks NIH protocol (  =12  ) better overall SNR –Pre- & post-contrast: more complex image –Segmentation easier? (CNR measurements) Coil placement important! Difficult? Pre-saturation slabs? Added acq. time? Older patients: –Many breathholds taxing to patient –Only 90 or 120 s post contrast?