1. Supplementary Fig. 2. Statistical Classification Analysis Results. Box and whisker plots displaying mean performance metrics returned in the assessment of in vitro AC 50 values and dosimetry- adjusted oral equivalent values in the prediction of the 28 continuous in vivo toxicity endpoints. Metrics assessed: mean absolute error and root mean squared error (RMSE) Forty SAS statistical classification models were used.* Detailed descriptions and parameters of the SAS models are provided in Supplementary Table 8; full names for the in vivo endpoints are provided in Supplementary Table 7.

2. In Vitro Oral Equivalent Dose – Continuous In Vivo Response Data (LEL) Fig. 8 In Vitro Nominal AC 50 and LEC Concentrations – Continuous In Vivo Response Data (LEL)

3. In Vitro Oral Equivalent Dose – Continuous In Vivo Response Data (LEL) Fig. 8 In Vitro Nominal AC 50 and LEC Concentrations – Continuous In Vivo Response Data (LEL)