1. Radionuclide angiography (RNA)
Gated equilibrium method (EqRNA)
First-pass method (FPRNA)

2. Gated equilibrium method (EqRNA)
Tc-99m labeled RBCs:
in vivo, in vitro, and modified in vivo approach
Tc-99m human serum albumin

3. Comparison of First-pass & Gated perfusion methods for evaluation of ventricular function
Needs 99mTc based agents as compact bolus injection
Needs high sensitivity detectors, programs
May be performed with rest and stress
LV & RV wall motion, volumes, and ejection fraction
Gated
May be performed with 201Tl or 99mTc based agents
Uses conventional cameras
Only LV wall motion, volumes, and ejection fraction
Provides LV wall thickening
Accuracy dependent on endothelial border definition

4. Dosimetry for Tc-99m Red Blood Cells
Organ Tc-99m Red Blood Cells
rad/mCi
Blood
Liver
Spleen
Bladder Wall
Testes
Ovaries
Heaart Wall
Total Body

5. Drug interfering with Tc-99m RBC labeling
Mechanisms
Heparin
Formation of labeled heparin
Methyldopa, hydralazine
Oxidation of stannous ion
Digoxin, prazosin, propranolol
unknown
Iodinated contrast media
Competitionn with anion transport system

14. First-pass method (FPRNA)
Tc-99m pertechnetate
Tc-99m DTPA or Tc-99m sulfur colloid
Short-lived agents:
Au-195m, Ir-191m, Ta-178

18. Infarction-avid imaging
Radiopharmaceuticals:
Tc-99m Pyrophosphate, 20 mCi, i.v.
Time of imaging:
3-4 hours after injection