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Penninger Fig. S1 a actin mkk7 +/++/--/- c b wild type allele mkk7 +/++/--/- neo allele 12 15 Kbp Neo HincII Probe Wild type allele Targeting vector Targeted.

Published byKenneth Cody Williams Modified over 8 years ago

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Presentation on theme: "Penninger Fig. S1 a actin mkk7 +/++/--/- c b wild type allele mkk7 +/++/--/- neo allele 12 15 Kbp Neo HincII Probe Wild type allele Targeting vector Targeted."— Presentation transcript:

1 Penninger Fig. S1 a actin mkk7 +/++/--/- c b wild type allele mkk7 +/++/--/- neo allele 12 15 Kbp Neo HincII Probe Wild type allele Targeting vector Targeted allele Neo XbaI Probe XbaI Liver x 200 Whole embryos x 5 p53 p-p38 p-ERK MDM2 +/- -/- +/- -/- d

2 0 h mkk7 +/- H 2 O 2, 48h 0 h G1: 55% S: 7.8% G2/M 37% mkk7 -/- H 2 O 2, 48h G1: 70% S: 12% G2/M 18% G1: 67% S: 14% G2/M 19% G1: 59% S: 10% G2/M 31% 0 1010 3030 4040 0480 (h) after H 2 O 2 mkk7 +/- mkk7 -/- G2/M (%) 20 a b UV TNF  mkk7 -/- +/++/--/-+/++/--/-+/++/- GST-c-Jun JNK 26 69 86 40 121 52 (kDa) The full scan for Fig. 2a The full scan for Fig. 2c MKK7 -/-+/++/--/-+/++/- mkk7pBabe mkk7 26 69 86 40 121 184 52 (kDa) The full scan for Fig. 2d MKK4 JNK (kDa) 26 69 86 40 121 184 52 26 69 86 40 52 +/--/- mkk7 + - - mkk4 MKK7  -actin 26 69 86 40 121 52 pBabe control mkk7 -/- mkk7 mkk7 +/+ control mkk7 control (kDa) The full scan for Fig. 3b Fig. S2 c def Penninger

3 52 69 86 40 121 184 p53 mkk7 +/++/--/- Jun D 61 86 49 121 184 mkk7 +/++/--/- ATF-2 52 69 86 40 121 184 mkk7 +/++/--/- mkk7 +/++/--/- MKK4 52 69 86 40 121 184 p38 61 26 86 49 121 mkk7 +/++/--/- c-Jun mkk7 +/++/--/- 61 36 86 49 121 184 Jun B 61 36 86 49 121 184 mkk7 +/++/--/- CycB1 52 28 69 40 mkk7 +/++/--/- MAPK 61 26 86 49 121 184 mkk7 +/++/--/- JNK 52 69 86 40 121 184 mkk7 +/++/--/- p-c-Jun mkk7 +/++/--/- 61 36 86 49 Cdc2 mkk7 +/++/--/- 61 36 86 49 121 32 Fig. S3 Penninger mkk7 +/- mkk7 -/- 147 p16 p21 CyclinD1 Cdc2 14710 61 36 86 49 121 32 61 36 86 49 121 32 26 15 32 20 36 26 15 32 20 The full scan for Fig. 4b The full scan for Fig. 4d JNK Cdc2 mkk7 +/- -/- +/- -/- GST- c-Jun HH1 +/--/- 61 26 86 49 121 +/--/- 61 26 86 49 121 Passage No. mkk7 +/- mkk7 -/- cdc2 18S 36 83 6 8 28S a b c d The full scan for Fig. 4c The full scan for Fig. 4a

4 Fig. S4 Penninger The full scan for Fig. 4g cdc2 mkk7 +/- -/- actin +/- -/- The full scan for Fig. 4f met hgf +/--/-+/--/- +/- -/- GST- c-Jun JNK 61 26 86 49 121 184 +/- -/- mkk7 The full scan for Fig. 6a 61 36 49 Actin Cdc2 36 49 32 mkk7 -/- Control c-Jun The full scan for Fig. 6c The full scan for Fig. 6b +/+ c-Jun 25 Passages 61 36 86 49 121 32 Cdc2 -/-AA -/-AA P-c-Jun +/+ -/-AA+/+ c-Jun -/-AA 25 Passages 61 36 86 49 121 32 28S wtJunAA 18S 468468 Passages cdc2 The full scan for Fig. 7d Actin c-Jun 61 36 86 49 121 32 61 36 86 49 121 32 pBabe control mkk7 -/- c-Jun mkk7 +/+ control a c d e f b

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