1. 1 The Center for Modeling Optimal Outcomes, LLC The material contained herein has been prepared in a tutorial format to explain The Center’s Model for Homeostasis Copyright 2009, The Center for Modeling Optimal Outcomes, LLC 1

2. Tacitly, everyone knows that homeostasis (equilibrium) exists. Scientifically, however, converting the tacit knowledge into an explicit, replicable model has not occurred. During the evaluation of neurobiology for the purpose of applying neuroscience in business, The Center’s team members identified a scientifically sound model for the dynamics of homeostasis. Copyright 2009, The Center for Modeling Optimal Outcomes, LLC Homeostasis Discovery 2

3. 3 In physics, sub-atomic particles (foundational substances/elements) are to all matter (compositional substances/elements) as, in biology, DNA and RNA (foundational substances/elements) are to amino acids, proteins, hormones, peptides, fatty acids, enzymes, neurons, bacteria, etc. (compositional substances/elements). All matter (substances, elements, etc.) are governed by the same irrefutable laws of physics and energy. The application of these laws in medical research, play a role in the causal paths of illnesses and diseases. Copyright 2009, The Center for Modeling Optimal Outcomes, LLC Biological Relativity

4. 4 Physics, chemistry and neuroscience state…. Copyright 2009, The Center for Modeling Optimal Outcomes, LLC

5. 5 Protons Sub-atomic Particles Are Based on the Laws of Energy Electrons Neutrons Copyright 2009, The Center for Modeling Optimal Outcomes, LLC

6. 6 Positive Charge Elements in the Periodic Table Are Based On the Same Laws of Energy Negative Charge Transition Elements Copyright 2009, The Center for Modeling Optimal Outcomes, LLC

7. 7 Efferent Neurons Neurons Are Based On the Same Laws of Energy Afferent Neurons Interneurons Copyright 2009, The Center for Modeling Optimal Outcomes, LLC

8. 8 Medical science knows that the body is comprised of matter and that the body is “powered” by a minute amount of electricity. Accordingly, the laws of physical science apply to medical research. The next slide illustrates a base pair (A and B) that must remain in balance for homeostasis to exist. Should any factor disrupt homeostasis, the body will react. As imbalances between substances in the body occur, processes take place in an effort to restore balance (homeostasis). Copyright 2009, The Center for Modeling Optimal Outcomes, LLC The “Laws” of Science

9. 9 Modulated Pair Illustration AB CModulator Copyright 2009, The Center for Modeling Optimal Outcomes, LLC

10. 10 What happens when two genes (proteins) such as HER-1 and HER-2 are imbalanced? Medical research has identified the outcome as one of the causes of breast cancer. Despite new drug therapies, this form of breast cancer involving disruptions in HER genes (proteins) has not been cured. Why? What if a modulator were involved that, if over expressed, would continue to cause the imbalance? What if that gene (protein) was comprised of a different molecular structure that might not be readily identified unless the researchers knew what to look for? Copyright 2009, The Center for Modeling Optimal Outcomes, LLC Compelling Questions

11. 11 GRB-7 or HER-3 (Modulator) HER-1HER-2 Cancer of the Breast (An Example of One Form) Cancer of the Breast (An Example of One Form) Copyright 2009, The Center for Modeling Optimal Outcomes, LLC

12. 12 One of the unknown aspects of epigenetics is the process that causes genes to turn on and off. While varying terminologies exist for the process, the biological dynamics occur when the modulator is activated (turned on) as opposed to being inactive (turned off). Our web site explains the specific dynamics for why “genes” are turning “on and off.” To provide an example that the modulated pair modeling process is universal, the next two slides have been included that illustrate minerals that are well known to the medical community. Copyright 2009, The Center for Modeling Optimal Outcomes, LLC Universality

13. 13 The results of a scientific study relative to sodium-potassium published in January 2009 provide insight into the dynamics of modulated pairs. http://www.sciencedaily.com/releases/2009/01/090126173839.htm Specific details regarding the consequences of disrupting the homeostatic relationship between sodium - potassium and chloride are provided by The Center in the “brief” for cardiomyopathy posted on the web site. Copyright 2009, The Center for Modeling Optimal Outcomes, LLC Sodium & Potassium 13

14. 14 Modulated Pair Demonstration Sodium Potassium Potassium Chloride(Modulator) Copyright 2009, The Center for Modeling Optimal Outcomes, LLC K Na 14

15. 15 Many variables must come together in order to create “perfect storm” scenarios that create causal paths for illnesses and diseases. This information has been selected to provide examples of how the modeling process for homeostasis can be applied to medical research. The model of homeostasis is universal. The Center has identified multiple modulated pairs related to several forms of cancer, neurodevelopmental and neurodegenerative diseases. Copyright 2009, The Center for Modeling Optimal Outcomes, LLC Important Points