1. A DAPTING PUBLISHED RESEARCH DATA TO A BIOINFORMATICS MODULE IN A UNDERGRADUATE BIOLOGY MAJOR ’ S COURSE N ATURE. 2011 M AY 26;473(7348):519-22 L ONG - TERM EVOLUTION AND TRANSMISSION DYNAMICS OF SWINE INFLUENZA A VIRUS. V IJAYKRISHNA D, ET AL. Natalia ToporikovaDenise Monti Carmen WrightSuzanne Hizer

2. A RESEARCH QUESTION TO DEFINE THE PROBLEM SPACE What changes occurred in the swine flu virus that allowed it to infect humans as H1N1 virus?

3. I DENTIFY THE PRIMARY INFLUENZA GENE THAT IS RESPONSIBLE FOR INFLUENZA TO BIND TO IT ’ S HOST CELL. Using MeSH terms to find primary research articles

4. W HAT DOES THIS GENE / PROTEIN DO ?

5. T HE PDB: MORE THAN JUST STRUCTURES

6. H OW IS YOUR GENE DIFFERENT OR THE SAME BETWEEN SWINE AND HUMAN H1N1?

7. E XPLORING THE ‘ MATH ’ BEHIND MULTIPLE SEQUENCE ALIGNMENTS http://www.hiv.lanl.gov/content/sequence/HIV/REVIEWS/2006_7/A BECASIS/abecasis.html

8. U SING PYTHON TO DEMONSTRATE SIMPLE SEQUENCE ALIGNMENT ALGORITHM

9. I DENTIFY THE VARIABLE REGIONS ON THE PROTEIN STRUCTURE FOR YOUR GENE

11. H OW DO YOU THINK THESE CHANGES ARE RESPONSIBLE FOR H1N1 INFECTIVITY IN HUMANS ?