1. Adiponectin versus angiotensin II: Key pathological role of their misbalance

2.  RAS inhibit adiponectin production  RAS interacts with adiponectin in their target cells

3. Ang Ⅱ inhibit adiponectin production Diabetologia (2005) 48: 1066– 1074

5. Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations Hypertension. 2003;42:76-81.

6. Mechanism:  Olmesartan, an Ang II type-1 (AT1) receptor blocker (ARB), inhibits overexpression of NADPH subunits and a transcriptional Factor -PU1 (which upregulates the transcription of NADPH oxidase subunits)  Olmesartan meliorates dysregulation of other adipokines, including tumor necrosisfactor-α, plasminogen activator inhibitor-1, serum amyloid A3, and monocyte chemotactic protein-1. Kidney Int 2006; 70:1717–1724.

7.  SomeARBs, including irbesartan and telmisartan,have PPARγ-activating properties, thereby stimulating adiponectin production. (Circulation. 2004;109:2054- 2057.)

8.  AT2 receptor activation in the absence of AT1 receptor activation. Journal of Neurochemistry, 2005, 94, 1395–1401

9. Acta Diabetol (2005) 42:S26–S32

10. Adiponectin-stimulated production of NO in BAEC is dependent on PI 3-kinase activity. JBC,2003, 278(45) 45021–45026 NO Production

11. Curr. Med. Chem. Cardiovascular & Hematological Agents, 2005, 3, 305-322

12. the proliferation of vascular smooth muscle cells Adiponectin inhibits PDGF-BB–induced HASMC proliferation and migration. Circulation. 2002;105:2893-2898.

14. Angiotensin II Signal Transduction Through Small GTP- Binding Proteins: Mechanism and Significance in Vascular Smooth Muscle Cells Ang II stimulates the ERK cascade through epidermal growth factor receptor transactivation Hypertension 2006; 48: 534–540.

15. Kidney International (2006) 70, 1678–1679.