1. Urinary system 1.Compounds and functions 2.Embryogenesis 3.Kidney 4.Nephrons types 5.Blood supplying 6.Glomerular filter 7.Nephrons histophysiology 8.Endocrine system of kidney 9.Urine transport system

2. Kidneys – urine production endocrine Ureters – voiding of urine Urinary bladder–urine deposition Urethra – voiding of urine Embryogenesis of urinary system Source – intermediate mesoderm (nephrogonotom ) Stages – pronephroi mesonephroi metanephroi

3. Kidney

4. MFU – nephron renal corpuscle+tubular system Types: 1. cortical – short and long 2. juxtamedullary Blood supply 1.25% of cardiac output 2.Two capillary systems (glomerular and peritubular) 3.High blood pressure in glomerulus

5. Renal cortex

6. Renal corpuscle

7. Renal corpuscle ultrastructure

8. Glomerular filter

9. Between circulating blood and urinary space Podocyte Basement membrane unusialy thick physical and electrical barrier Endothelium fenestrated

10. Proximal convoluted tube

12. Distant convoluted tube

13. Urine production StagePlaceMechanism Filtration Renal corpuscle High blood pressure Absorp- tion Tubules Active – by cells Passive – onkotic pressure Secre- tion Collecting tube H+H+

14. Endocrine system of kidneys Renin-angiotensin Prostaglandins Callicrein-kinins Erythropoietin Juxtaglomerular apparatus 1.Juxtaglomerular cells 2.Juxtavascular cells 3.Macula densa area 4.Mesangial cells

17. Urine transport system Renal pelvis Ureters Urinary bladder Urethra Tunics I Mucosa: epithelium (urothelium) lamina propria muscularis mucosa II Submucosa III Muscular IV Adventitia