1. Neuregulin and Schizophrenia

2. Schizophrenia Debilitating mental illness affecting 1 % of the general population across the world. Onset in adolescent age. Symptoms Positive symptoms –Hallucinations, delusions Negative symptoms –Avolition, Apathy Disorganization symptoms –Inappropriate social behavior Cognitive deficits –Perceptual deficits - Visual, Auditory. –Deficits in memory. –Emotional changes.

3. Schizophrenia is associated with many alterations in brain structure and function. Many regional reduction in gray matter. Thompson et al.,, 2001 Achim et al.,, 2005 Reduction in brain activation during cognitive tasks Van der stelt et al.,, 2005

4. Genetics of Schizophrenia Kirov et al.,, 2003

5. Neuregulin 1 – Linkage in 8p Stefansson et al., 2002

6. Harrison et al., 2006

8. Functions of Neuregulin

10. Flames et al., 2004

11. Chih et al., 2004

13. Michailo et al., 2004

14. Conclusions Evidences so far, show NRG plays a vital role in neurodevelopmental processes. Association with Schizophrenia and late onset Alzhimer’s suggest a link between this gene and various diseases of nervous system. The role of NRG is still being studied. Further studies are required to identify its mechanisms of action.

15. Catpa demo….