1. Rumex International Co. Bridge between innovative technology and perfect surgery Rumex International Company 13770 58th Street North, Suite 317 Clearwater, FL 33760, USA shop@rumex.net www.rumex.net

2. 2 Rumex OVDs. SmartVisc, SmartVisc+ CE Marked November 2011 1.0 ml

3. 3 www.rumex.net SmartVisc, SmartVisc+ Are viscoelastics based on sodium hyaluronate from biotechnical fermentation and are free of pyrogenic substances. SmartVisc 1.6% Sodium hyaluronate SmartVisc+ 3.0% Sodium hyaluronate

4. 4 www.rumex.net SmartVisc, SmartVisc+ Will help you maintain the important working space! * Ability to deepen the anterior and posterior chambers to allow for easier capsulorhexis and lens implantation * Excellent tissue manipulation * Completely transparent to enhance visualisation during cataract and vitreoretinal surgery * Asrpiration is quick and easy. Additionally, there is less chance for trapped viscoelastic behind the optic.

5. 5 www.rumex.net

6. 6 SmartVisc 1,6% Technical data: Sodium Hyaluronate: Molecular Weight: Viscosity: Osmolarity: Storage: pH: Volume: Shelf life Cannula 1.6% 1.2 – 2.0 mill. Daltons aprox 80.000 mPs 270 - 400 mOsm/kg 2 – 25°C 6.8 - 7.4 1.0 ml 3 years 27 gauge Formula: 1 ml contains Sodium hyaluronate Sodium chloride Disodium hydrogenphosphate Sodium dihydrogenphosphate Water for injection 16.000 mg 8.500 mg 0.563 mg 0.045 mg q.s High cohesion for easy irrigation / aspiration Soft coating and protection of endothelial cells

7. 7 www.rumex.net SmartVisc + 3.0% Technical data: Sodium Hyaluronate: Molecular Weight: Viscosity: Osmolarity: Storage: pH: Volume: Shelf life Cannula 3.0 % average 1.0 - 1.8 million Dalton aprox 400.000 mPs 270 – 400 mOsm/kg 2 – 25°C 6.8 - 7.4 1 ml 3 years 27 gauge Formula: 1 ml contains Sodium hyaluronate Sodium chloride Disodium hydrogenphosphate Sodium dihydrogenphosphate Water for injection 30.000mg 8.500 mg 0.563 mg 0.045 mg q.s. High cohesion for easy irrigation / aspiration Soft coating and protection of endothelial cells High Viscosity

8. 8 www.rumex.net Features Two different viscosities (80&400) can provide Viscoelastic Soft Shell Technique Low molecular weight - easy to remove after surgery Ultrapure Hyaluronic Acid with highest biocompatibility Clear view of posterior capsule during phacoemulsification No refrigeration necessary – storage 2-25° Volume: 1 ml

9. 9 www.rumex.net Competitors in the global market BrandProducerVolume of Syringe MW (D)CompositionStorageCohesiveDispersive ProviscAlcon Labs, USA 0.4;0.55;0.852 500 0001 % NaHa2-8°C+- ViscoatAlcon Labs, USA 0.5600 0003 % NaHa, 4 % CDS 2-8°C-+ DisCoviscAlcon Labs, USA 0.5;1.01 650 0001.7 % NaHa, 4 % CDS 2-8°C++ HealonAMO, USA0.4;0.55;0.854 000 0001 % NaHa2-8°C+- Healon GVAMO, USA0.55;0.855 000 0001.4 % NaHa2-8°C+- Healon 5AMO, USA0.64 000 0002.3% NaHa2-8°C++ AmviscBausch&Lomb, Incorporated, USA 0.82 000 0001.2 % NaHa2-8°C+- Amvisc PlusBausch&Lomb, Incorporated, USA 0.81 500 0001.6 % NaHa2-8°C+- MultiviscBVI, USA0.67 900 0002.5% NaHa2-8°C++ OVD1.2%BVI, USA1.03 000 0001.2 % NaHa2-8°C+- SmartViscRumex Int. Ltd, UK1.01 200 000- 2 000 000 1.6% NaHa2-25 °C+- SmartVisc+Rumex Int. Ltd, UK1.01 000 000- 1 800 000 3.0 % NaHa2-25 °C+-

10. 10 www.rumex.net Rumex OVDs. SUPREME CE Marked November 2011 Supreme is a viscoelastic solution of high molecular weight, highly purified grade of hydroxypropyl methylcellulose 2%, clear, isotonic, sterile, non inflammatory and non-pyrogenic in nature. It is used for intraocular injection during anterior segment surgery of the eye.

11. 11 www.rumex.net Product Features Supreme is a medical device used in the anterior segment surgery of the eye. It has the following unique characteristics:

12. 12 www.rumex.net Properties: Molecular Weight86,000 daltons Dynamic Viscosity 3000 – 4500 cPs at 27 ⁰ C pH6.0 – 7.8 Osmolality250-350 mosmol/Kg Volume2 ml pre-filled glass syringes in double pouch packing

13. 13 www.rumex.net Competitors in the global market BrandProducerVolume of Syringe (ml) CompositionViscosity (mPas) MW (D) CellugelAlcon Labs., USA) 1.02% НРМС30 000±10 000300 000 OcucoatBausch & Lomb, USA 2.02% НРМС4000 ±150092 000 AppaviscAppasamy, India 3.03.02% НРМС20007000 Metilon20BioTech, India2.02% НРМС420086000 Metilon24BioTech, India2.02.4% НРМС420086000 SupremeRumex Inc. Ltd, UK 2.02% НРМС3000-450086000

14. 14 www.rumex.net Rumex International Company 13770 58th Street North, Suite 317 Clearwater, FL 33760, USA USA, Canada: Tel: +1 (727) 568 0909 Toll Free: +1 (877) 77 RUMEX Fax: +1 (727) 568 0919 Europe, Asia, Africa, Latin America: Tel: +371 6616 3182