1. DNA Replication http://www.wiley.com/college/pratt/047139 3878/student/animations/dna_replication/in dex.html http://www.wiley.com/college/pratt/047139 3878/student/animations/dna_replication/in dex.html

2. Structure of DNA Review

3. Antiparallel Nature of DNA

4. Complimentary Base Pairing

5.  DNA replication ensures the continuity of hereditary information.  Replication occurs as cells prepare to divide, during the S phase of interphase.  The replication process is semiconservative, where one strand serves as a template for a new, complimentary strand.  Replication requires many enzymes, occurs bidirectionally, and differs in production of the leading and lagging strands.  The result of DNA replication is 2 new strands of DNA, each with ½ old DNA and ½ new DNA. Continuity of Heredity Info

6. How does this diagram depict the semi- conservative nature of DNA replication? Semiconservative Replication

7. Origins of Replication

8. Replication Enzymes

9. Priming DNA Synthesis

10. Leading & Lagging Strand

12. 1. DNA polymerase elongates DNA strands only in the 5’ → 3’ direction. 2. One new strand (leading strand) can therefore elongate continuously 5’ → 3’ as the replication for progresses. 3. The other new strand (lagging strand), must grow in an overall 3’ → 5’ direction by addition of short segments (Okazaki fragments) that grow 5’ → 3’ (numbered here in the order they were made). 4. Ligase connects the Okazaki fragments.