1. BioSense 2.0 Technical Update  To access the slides for today’s presentation, go to: https://sites.google.com/site/biosenseredesign/training/tra ining-library (the document name is “Technical_Update.pptx”) https://sites.google.com/site/biosenseredesign/training/tra ining-library  Questions may be submitted via the chat feature. Please try to hold questions until the Q&A portion of the webinar. Any questions we cannot answer on today’s webinar will be answered and posted to the Collaboration Site. Technical questions related to webinar difficulties may be submitted via the chat feature at any time.

2. Technical Update Nabarun Dasgupta, MPH

3. Encephalitis, Meningitis, WNV = CNS Inflammatory Disease

4. Simple Time Series Smoothing

5. Concurrent Public Health and News Reports Confirm

6. Saved View for Quick Retrieval Later

7. Analysis Looking at Sex Differences

8. Finding Patterns in the Data

9. Age Distributions Help Characterize Outbreaks

10. Sharing Views and Exporting Data Access Controlled

11. Advanced Features  RStudio statistical package can directly interface with ADM Webinar available at: BioSenseRedesign.org  Fit regression models for estimating rates and testing hypotheses  State-level lockers allow unique data storage and sharing needs (PHPMyAdmin)  Line-level data available

12. Data Sharing Control  Share nothing, visit, county, or state-level data  Optional CDC share  Customize data sharing with other jurisdictions  Quick changes

13. Account Control  Account verification  Email confirmation  Quick activation and deactivation for changes in employment

14. BioSense Redesign Architecture and Data Flow (Jurisdictional Lockers and Binned Lockers) Mike Alletto BioSense 2.0

15. Data Input Data Providers PHIN-MS NwHIN-Connect and Direct SFTP Mirth-to-Mirth VPN HTTPS AWS cloud BioSense 2.o system hosted in the Amazon cloud

16. Data Matriculation Stage Stage 1Stage 3Stage 2 Meaningful Use Base Table Jurisdictional Locker (record-level data) AWS cloud

17. Jurisdictional Locker Locker

18. Automatic Processing Binned Locker (visit records) Normalization Process AWS cloud

19. Update on BioSense 2.0 Onboarding Barbara L. Massoudi, MPH, PhD BioSense Redesign Team, Project Director

20. BioSense 2.0 Data Use Agreements (DUA) and Grant Recipients Signed DUA for BioSense 2.0, N=35 DUA Officially Under Review, N=18 Engaged in Ongoing Review Local Public Health Jurisdiction BioSense 2.0 Cooperative Agreement Recipients, N=35 November 19, 2012

21. BioSense 2.0 by the Numbers StateLocal Signed DUAs287 DUA officially under review153 Jurisdictions transmitting data regularly103 Onboarding in process (may have some facilities transmitting regularly) 156

23.  Jurisdictions may join BioSense 2.0 at no cost.  Staff time will be necessary for initial setup of BioSense 2.0 for tasks such as signing data use agreements (DUAs) and working with data providers  Due to volume of interest, priority is currently given to jurisdictions with signed DUAs. We must have data and security stewards identified to begin technical discussions.  Onboarding library: https://sites.google.com/site/biosenseredesign/onboarding /onboarding-library https://sites.google.com/site/biosenseredesign/onboarding /onboarding-library

24. Upcoming BioSense 2.0 Webinars  Tuesday, February 19 th at 12:30 pm EDT, “Change Point Analysis”  For more information or to register, please visit our Collaboration Web Site www.biosense2.orgwww.biosense2.org  If you have any suggestions for future webinars, please contact us at info@biosen.seinfo@biosen.se