1. 7 월달 weekly case Tae Yong Moon, M.D. Pusan National University Hospital

2. Age/Sex : 27 year-old male CC : Left radiating pain for 2 months

5. T1 T2FST1-Gd DTPA FS

6. T1

7. Radiological impression of Lumbar and hip MR before excisional biopsy ; hematologic disorder such as leukemia, lymphoma, multiple myeloma Radiological impression of lung CT before biopsy ; active cavitary pulmonary tuberculosis

8. Pathological Diagnosis Langerhans’ cell histiocytosis (LCH) by excisional iliac bone biopsy Langerhans’ cell histiocytosis (LCH) by lung biopsy

9. Discussion LCH of bone is a disorder of histiocytic proliferation with variable and often unpredictable behavior. Ranged from 3 months to 50 years old (mean, 12 years; median, 10 years) in 245 patients by Mayo Clinic. The skull was the most frequent osseous site. Diabetes insipidus was documented in 12% of the patients.

10. References Kilpatrick SE, Wenger DE, et al. Langerhans’ cell histiocytosis (histiocytosis X) of bone. A clinicopathologic analysis of 263 pediatric and adult cases. Cancer 1995; 76:2471-84 Baillet A, Grange L, Lafaix PA, Gaudin P, Juvin R. Radiculopathy as a manifestation of Langerhans’ cell histiocytosis. Joint Bone Spine 2007; 74: 190-3 Hamre M, Hedberg J, Buckley J, et al. Langerhans cell histiocytosis: an exploratory epidemiologic study of 177 cases. Med Pediatr Oncol 1997; 28: 92-7 Dacic S, Trusky C, Bakker A, et al. Genotypic analysis of pulmonary Langerhans cell histiocytosis. Hum Pathol 2003; 34: 1345-9