1. Biology 475/475 Neurobiology Dr Grant Mastick Dr Grant Mastick –FA 311D, X6168 –gmastick@unr.edu gmastick@unr.edu –Send me an email: First assignment will be sent by email on Wed First assignment will be sent by email on Wed Course website Course website –http://med.unr.edu/homepage/gmastick/ BIO475page/index.html http://med.unr.edu/homepage/gmastick/ BIO475page/index.htmlhttp://med.unr.edu/homepage/gmastick/ BIO475page/index.html

2. BIOL 475 Neurobiology A brief overview of course

3. What is neurobiology? Psychology and the “black box” Psychology and the “black box” –Behavioral, Cognitive –Physiological Psychology Physiological PsychologyPhysiological Psychology Biology: Biology: –Approach of “reduction”: take apart the box –Goal: understanding underlying mechanism for nervous system function This course: cellular and molecular neurobiology This course: cellular and molecular neurobiology

4. My main goals Integrate cellular and molecular biology topics Integrate cellular and molecular biology topics Training in scientific reasoning Training in scientific reasoning –Hypotheses, experiments, interpretation Learn about brain structure and function Learn about brain structure and function –Understanding how neurons function

5. Topics in course Cell biology of neurons Cell biology of neurons Developmental neurobiology Developmental neurobiology Neurophysiology Neurophysiology Sensory and motor functions Sensory and motor functions Frontiers of neurobiology Frontiers of neurobiology

6. 1. Cell biology of neurons Neurons: basic parts Neurons: basic parts –Cell body –Axon: output Long, unbranched Long, unbranched –Dendrite: input Shorter, highly branched Shorter, highly branched Distinct shape for each neuron type Distinct shape for each neuron type –Thousands of distinct types of neurons How is this regulated? How is this regulated?

7. 1. Cell biology of neurons Incredible specialized cells in nervous system Incredible specialized cells in nervous system Glia example: myelin insulates axons Glia example: myelin insulates axons Glial cell: Schwann cell, “unrolled” axon Myelin sheath

8. 2. Development of nervous system The embryonic brain: The embryonic brain: –billions of neurons self-assemble into functional nervous system Wiring the brain: the growth cone leads the axon to its target Wiring the brain: the growth cone leads the axon to its target Growth cone: “Amoeba on a string” Crawls through brain, leaving axon trailing behind Navigates using chemical cues to find target cell

9. 3. Neurophysiology How neurons signal to other cells How neurons signal to other cells –Other neurons, muscles, glands, blood vessels Critical electrical signal is the Action Potential Critical electrical signal is the Action Potential –Firecracker analogy –Driven by ions passing through ion channels –Electrical signal driven along very long axons to target cells –Guest lecturer: Dr Jim Kenyon, UNSOM –Axon computer lab

10. 4. Sensory and motor functions Sensory: Sensory: –Physical (or chemical) cues from outside world –Enter nervous system through sensory neurons Light to photoreceptors; smell to chemoreceptors Light to photoreceptors; smell to chemoreceptors Motor: Motor: –Nervous system sends signals to muscles

11. Visual processing Optical illusion: Optical illusion: Retinal ganglion neurons Retinal ganglion neurons –Gather signals from small area of retina –Integrate (add up) signals –Center-surround

12. 5. Frontiers of Neurobiology Beginning of understanding on cellular and molecular levels Beginning of understanding on cellular and molecular levels –Normal processes Learning and memory Learning and memory What is “learning”? What is “learning”? –Neurological diseases Guest lectures: Alzheimer’s disease, Schizophrenia Guest lectures: Alzheimer’s disease, Schizophrenia