1. ESOPHAGEAL DISEASES Prof. Saleh M. Al-Amri Consultant, Gastroenterology Unit College of Medicine & K.K.U.H. King Saud University

2. Esophageal Diseases Two function of esophageal - Transport of food by peristalsis. - Prevention of gastric regurgitation by LES/UES. Dysphagia: * Sensation of obstruction of food passage. * Difficulty in swallowing

3. A) Mechanical dysphagia my be due to: 1. Large food bolous. 2. Instrinsic narrowing. e.g. i) Esophagitis (viral/ fungal) ii) Stricture (benign) iii) Tumor iv) Web/ rings

4. 3.Extrinsic compression e.g. i) Enlarge thyroid. ii) Diverticulum. iii) Left atrial enlargement.

5. B) Motor dysphagia: Diseases of striated or smooth muscles of esophagus Striated muscle disease * Motor neron dis * CVA * Myasthenia gravis * Polymyositis

6. Smooth muscles disorder: * Scleroderma * Achalasia * Esophageal spasm

7. History can help DD:  Difficulty with solids implies mechanical dysphagia / which may progress / static.  Motor dysphagia, equally affect solid and liquid from the onset.

8. Character: Episodic dysphagia to solid for long duration – esophageal ring.  Nasal regurgitation – Pharyngeal paralysis  Tracheobronchial aspiration – Achalasia – Zenker diverticulum  Severe weight loss – Malignancy  Horseness and dysphagia – Recurrent laryngeal nerve involvement by malignancy.

9. Physical examination:  Sign of bulbar paralysis  Dysarthria  Ptosis  CVA  Goitre  Changes in skin - CTD

10. Odynophagia: Painful swallowing which is characteristic of non-reflux esophagitis. Heartburn: Burning sensation Moves up/down Chest pain:  GERD  Esophageal motor disorder.

11. Haematemesis. Melena. Regurgitation.

12. GERD (Gastro-oesophageal reflux disease) Reflux esophagitis: Damaged esophageal mucosa by reflux of gastric content. Pathophysiology Antireflux mechanism includes:  LES  Esophageal peristalsis  Resistant of esophageal mucosa.  Saliva  Gastric peristalsis

13. Major factor involved in GERD  Loss of LES pressure: TLESR Sustained Scleroderma Surgical resection  Hiatus hernia  Aperistalsis  Reduce saliva  Delayed gastric emptying : Mech. Obstruction and motor disorder.

14. Damage depends on:  Refluxed material  Duration of reflux / frequency.

15. Manifestation:  HB  Chest pain  Dysphagia - complication  Regurgitation

16. Diagnosis: Endoscopy & Biopsy Barium swallow 24 Hours pH - motility

17. Complication:  Bleeding  Stricture formation  Barrett’s esophagus

18. Treatment:  Antireflux measure.  Acid supressing agent.  Surgery

19. Achalasia: A motor disorder of esophageal smooth muscle Character by:  High LES pressure, that does not relax properly.  Absent distal peristalsis.

20. Pathophysiology: Loss of intramural neurons of esophageal body & LES. Clinically  Dysphagia – both liquid and solid.  Regurgitation and pulmonary aspiration.  Chest pain.

21. Diagnosis: Chest X-ray -  Absent of gastric bubble.  Wide mediastinum.  Fluid level. Ba. Swallow Esophageal dilatation Terminal part of the esophagus is beak like

22. Manometry Elevated LES P with no or partial relaxation low amplitude contraction, no propagating (simultaneous).

23. III. A) Medical Nitroglucerin Ca – channel blocker. B) Pneumatic dilatation C) Surgical

24. Infectious Esophagitis: A) Viral esophagitis  Herpes simplex.  Varicella Zoster.  CMV.

25. B) Bacterial C) Fungal C/o - Dysphagia - Odynophagia - Bleeding

26. Diagnosis: Ba. swallow End. Bx.

27. Diverticula: Outpouchings of the wall of the esophagus Zenker - upper Epiphrenic – lower part C/o - Asymptomatic Typical – Regurgitation of food consumed several days ago. – Dysphagia.

28. Esophageal Cancer: Disease more in Males > 50 Y. Causation factors:  Excess alcohol.  Cigarette smoking.  Fungal toxin.

29. Mucosal damage:  Hot tea.  Radiation induced stricture.  Barrett’s esophagus.  Esophageal web.

30. Clinically 15% in upper 1/3 45% in middle 1/3 40% in lower 1/3 Pathology Squamous cell carcinoma > 75% adenocarcinoma  Progressive dysphagia  Weight loss  Odynophagia  Regurgitation  T-E Fistula

31. Once symptom appear the disease is incurable. Patient may have Hypercalcaemia Diagnosis:  Ba. swallow  Endoscopy & Bx

32. IV. - Surgical, if localized - Paliative Prognosis in poor. 5 Y survival  5%