1. cceHUB Sharing, Exploring and Analyzing Data An Environment for Collaborative Cancer Research clinical dataobservational & scientific data decision supportcomputation & visualization Ann Christine Catlin 6 th Annual Cancer Care Engineering Retreat 05-27-2011

2. Great Graduate Students ! Ruchith Fernando Lancelot Guoheng Chen Sahan Gamage Sudheera Fernando Puneet Gupta Sumudinie Fernando Preeti Rao Nabeel Yousef

3. cceHUB Advances in 2001 Clinical Patient Data & Sample Tracking More detailed and more complete data collection : diagnosis, treatment, surgery, follow-up New type of data : behavior lifestyle Customized projects: tissue acquisition

4. Tissue Acquisition : Clinical Data & Biorepository with Tracking

5. Data Collection : New Data … More Detailed Data

6. cceHUB Advances in 2001 Laboratory Data Upload & Tracking Repository size >1 TB Security upgrades Data verification and validation Metadata collection Help with lab uploads … e.g., mass spectrometry data Always looking for ways to make uploads easier, more complete, and more accessible to analysis tools.

7. Lab #Samples Analyzed % Total Files/ Samples Uploaded Average File Size Analysis Tools at cceHUB Using cceHUB tools ? Bindley Biosciences Global Proteomics 193 73%193 files 193 samples 80MBDiscovery Pipeline Results Visualize/Compare > 800 runs through discovery pipeline Teegarden Vitamin D 225 85%4 files 225 samples < 1MBVitamin D-Blood Draw - Clinical Data merge for SAS DataView Raftery Metabolomics GCGC-MS 230 87%230 files 230 samples 1 GBPeak classification /alignment GCGC-MS Visual Analytics Raftery Metabolomics NMR 230 87 %2 files 230 samples < 1MB Xu Lipidomics 143 54%1 file 143 samples < 1MBLipidomics-BloodDraw- Clinical Data merge for SAS DataView Klaunig TEAC analysis 259 98%1 file 259 samples < 1MBTEAC-Blood Draw-Clinical Data merge for SAS DataView Klaunig Comet Assay 101 38%1 file 101 samples < 1MBCometAssay-Blood Draw- Clinical Data merge for SAS DataView Klaunig Genotyping Assay --POCRE, MaCH genotype imputation (used by stat group on their own data) Other: Laurie Parker Medicinal Chemistry and Molecular Pharmacology --Maldi Quantifier Laboratory data at cceHUB: Some Statistics

8. Laboratory data at cceHUB: Metadata

9. cceHUB Advances in 2001 Analysis Tools / Analysis Data Collections Proteome Discovery Pipeline Analysis Data Viewer Building models & generating results Output collections for tools New tools: MacH, Mach Results Visualization, POCRE, Maldi Quantifier, specialized plotting tools

10. New Analysis Tools

11. Analysis Data Viewer

12. Tool Output Collections for Browsing and Analysis

13. Collaboration : Sharing Idea for Analysis, Getting Results

14. Our technology extends to other cancer research workflows Using the HUB cyber infrastructure with cceHUB data technology to further collaborative Cancer Care Engineering Research