1. SANBI Glossina genomics workshop Cape Town 04-08 August 08 1 SANBI Glossina comparative genomics workshop: TDR new strategy and vector research operational plan Yeya T. Touré WHO-TDR (tourey@who.int)

2. SANBI Glossina genomics workshop Cape Town 04-08 August 08 2 Outline of the presentation 1.TDR new vision and strategy 2.Business Line 5: Innovative vector control interventions: Objectives, activities and operational plan

3. SANBI Glossina genomics workshop Cape Town 04-08 August 08 3 TDR new vision and strategy

4. SANBI Glossina genomics workshop Cape Town 04-08 August 08 4 Track record Supported >10,000 projects; trained >1,500 PhD scientists Five of 10 tropical diseases targeted for global / regional elimination Mission To develop new and improved tools for tropical disease control To strengthen the research capability of disease endemic countries (DECs) TDR was established as a special programme 30 years ago Key strengths UN’s convening power Location in WHO and links to ministries and control Partner network and brokering capabilities Long-standing DEC relationships Governance structure

5. SANBI Glossina genomics workshop Cape Town 04-08 August 08 5 TDR Vision and Strategy www.who.int/tdr

6. SANBI Glossina genomics workshop Cape Town 04-08 August 08 6 TDR Vision To foster: An effective global research effort on infectious diseases of poverty in which disease endemic countries play a pivotal role

7. SANBI Glossina genomics workshop Cape Town 04-08 August 08 7 Strategic objectives Innovation Interventions Access

8. SANBI Glossina genomics workshop Cape Town 04-08 August 08 8 Stewardship / Priority Setting

9. SANBI Glossina genomics workshop Cape Town 04-08 August 08 9 Empowerment through: Training, Institutional Support and Networks Research systems (quality assurance)

10. SANBI Glossina genomics workshop Cape Town 04-08 August 08 10

11. SANBI Glossina genomics workshop Cape Town 04-08 August 08 11

12. SANBI Glossina genomics workshop Cape Town 04-08 August 08 12 Business Line 5: objectives, activities and operational plan

13. SANBI Glossina genomics workshop Cape Town 04-08 August 08 13 BL 5 strategic objectives Overall objective: To develop and evaluate improved and innovative vector control methods for the prevention of neglected diseases. Specific objectives: To promote the development and testing of new methods for improving Human African Trypanosomiasis (HAT) vector control and support the generation and exploitation of Glossina genome sequence data To advance the development and evaluation of new and improved integrated methods for malaria and dengue vector control To progress the development and evaluation of alternative methods for the prevention of re-infestation and the control of Chagas disease vectors

14. SANBI Glossina genomics workshop Cape Town 04-08 August 08 14 Development and evaluation of improved vector control methods Building capacity in biosafety, exploitation of vector genome data, training within funded grants Facilitating the Glossina genome sequencing initiative

15. SANBI Glossina genomics workshop Cape Town 04-08 August 08 15 Consultation meeting defined BL 5 activities and operational framework HAT (Human African Trypanosomiasis): - Improving bait technology, odour release systems and trapping materials for the enhancement of effectiveness of tsetse fly trapping - Improving the efficacy of HAT vector control programs through evidence-based planning and implementation of control strategies Genetic modification of malaria and dengue vectors: - Addressing the requirements for deployment of genetic control methods Malaria: - Developing and evaluating tailored methods for integrated malaria vector control - Characterizing malaria vector resistance to insecticides Dengue: - Improving methods for targeted and integrated dengue vector control approaches Chagas disease: - Developing improved methods for the prevention of re-infestation by triatomine bugs - Developing new methods for control of Chagas disease vectors Consultation on a framework for transition from current activities and implementation of the new vector research strategy Geneva, 23-24 April 2007

16. SANBI Glossina genomics workshop Cape Town 04-08 August 08 16 Objective 1: HAT vector control: Activities, end- products and milestones