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©2011 University of Illinois Board of Trustees

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1 ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

2 ATP: Thermochemistry and Electrochemistry for High School Students ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

3 Functions of ATP “Life’s battery” Stores potential energy for later use This energy can be used to perform various kinds of work Why is ATP suited for energy storage? ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

4 ATP Hydrolysis ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

5 Functions of ATP Muscle contraction ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

6 Functions of ATP Signal transduction – MANY EXAMPLES of kinases – Inflammation, for one ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

7 Functions of ATP Signal transduction – MANY EXAMPLES of kinases – Cancer cell signaling, for another ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

8 The Philadelphia Chromosome – Seen in Chronic Myelogenous Leukemia (CML) ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

9 Gleevec – the “magic bullet” May 2001 ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

10 The Bcr-Abl fusion protein product and Gleevec Cancer ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

11 Success Rate of Gleevec Cecil Medicine, 23rd ed ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

12 Functions of ATP Active transport of nutrients, electrolytes Example – sodium potassium ATPase – Responsible for maintenance of the resting membrane potential in human cells Na + /K + ATPase Animation 3D Structure of the Na + /K + ATPase ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

13 An interesting aside The Foxglove plant – Digitalis purpurea Digitoxin, an inhibitor of the Na + /K + ATPase ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

14 An interesting aside One of the side effects of digitalis intoxication is xanthopsia – a visual disturbance that causes the world to look yellow, similar to looking through a yellow filter. Other visual side effects include glare and colored haloes. Interestingly, some have argued that Vincent Van Gogh may have experienced these side effects after being treated with digitalis and this may account for some stylistic aspects of his art – including his propensity to use yellow colors and the colored haloes seen in his paintings. http://www.psych.ucalgary.ca/pace/va-lab/AVDE-Website/VanGogh.html ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

15 Nernst Equation Excel Activity Use the Nernst equation and Excel to examine what happens to the membrane potential as extracellular potassium levels change ©2011 University of Illinois Board of Trustees http://islcs.ncsa.illinois.edu/copyright

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