1. 1 PILOTING RANDOM SAMPLING TO DIVERSIFY A COMMUNITY REGISTRY AND BIOREPOSITORY: CHANGING THE LANDSCAPE FOR PARTICIPANT RECRUITMENT L.B. Bouk 1, P.B. Nunes 1, M. Cornish 1, M. Smerek 1, K. Ellis 1, J. Tenenbaum 1, A. Dunham 1, R. Dolor 2, V. Christian 1, R. Califf 1, L.K. Newby 2 1 Duke Translational Medicine Institute; 2 Duke Department of Medicine The MURDOCK Study is funded by the David H. Murdock Institute for Business and Culture and the Duke CTSA grant(UL1TR001117). The MURDOCK Study Community Registry and Biorepository is working to enroll 50,000 (current ~10,400) adult residents whose annotated biological samples and data can be accessed for –omic, population, and epidemiological studies. It is critical that the recruited cohort be representative of the local population with selection of a relatively unbiased population-based sample. Methods Recruit adult volunteers 18 years and older in designated geographic region of North Carolina to participate in a community registry and biorepository. www.murdock-study.org Random samplings of households (Pilots 1 and 2) recruited participants in eligible zip codes over a 12-month period to provide insight into the feasibility of methods for a full representative sample of the population (N=15,000 individuals from ~7500 households). One hundred households were targeted in each pilot effort to test outreach approaches, staffing models, marketing techniques and the role of door-to-door visits in representative sample recruitment. Individuals in all randomly selected households were given the opportunity to learn more about the study, schedule a visit or enroll on- site in their homes. Outcome: % of households interested (agreed to review study materials), not interested, unable to contact, or from which at least one participant was enrolled. Discussion Our pilot random sample studies showed that traditional techniques require refinement and more participant-directed approaches are needed to improve the efficiency of random sample recruitment before a full-scale population random sampling of households is undertaken. Applying ambassador feedback and lessons learned, Pilot 3 is now underway and is targeting two distinct neighborhoods and employing organized MURDOCK Study sponsored community events, increased visibility of yard signs and new marketing materials. Pilot 1Pilot 2Pilot 3 Zip code 28081 (Kannapolis) 28215 (Charlotte) 28027 (Concord) (2 distinct neighborhoods) Incentive $10 and $40 gift cards (randomly selected to house) $10 gift card Process 100 brochures mailed via USPS, followed by postcard reminders and phone calls 100 FedEx packets including letter, flyer, magnet Door-to-Door Visits with Ambassador 30 days from initial mailing No 7 days from FedEx mailing Yes 7 days from FedEx mailing Yes Advertising Methods None Yard signs, flyers at local retail Yard signs; flyers at local retail + community weekend event Enrollment Results 32% interested, 28% not interested, 40% unable to contact, 0% enrolled 47% interested, 22% not interested, 31% unable to contact, 9% enrolled TBD