1. CIRCULATION

2. Blood Plasma Blood cells Red blood cells White blood cells Granulocytes Neutrophils Eosinophils Basophils Agranulocytes Lymphocytes Monocytes Platelets

3. CharactersErythrocytes (RBC) Leucocytes (WBC) Thrombocytes (Platelets) ShapeCircular, biconcave, non-nucleated Colorless, Nucleated, Amoeboid Round, Biconvex, non- nucleated Size7um diameter 2.5um thick 8 – 15 um2.5 – 5 um diameter Amount in blood 5.1 -5.8 million/mm 3 of blood(males) 4.3 -5.2 million/mm 3 of blood(females) 5000 to 9000/mm 3 of blood 2.5 lakh/mm 3 of blood Life span120 days3-4 days5-10 days FormationErythropoiesisLeucopoiesisThrombopoiesis Place of formation Foetus: liver / spleen Adults: red bone marrow Red bone marrow, spleen, lymph nodes, tonsils, thymus, payer’s patch From large cells called megakaryocytes of bone marrow Increase of cellsPolycythemiaLeucocytosisThrombocytosis Decrease of cellsErythrocytopeniaLeucopeniaThrombocytopenia

4. GRANULOCYTES ChracterNeutrophilEosinophilBasophil Granules stainedWith neutral dyesWith acidic dyesWith basic dyes Shape of nucleus3-5 lobes (polymorphic) BilobedTwisted or “S” shaped Constitute70% of WBC3% of WBC0.5% of WBC FunctionPhagocytic Engulf microorganisms Anti-histamine property Release heparin and histamine Show granular cytoplasm Bilobed nucleus

5. AGRANULOCYTES Absence of granules in cytoplasm Nucleus is not lobed CharactersLymphocytesMonocytes (Largest WBC) Shape of nucleusRoundKidney shaped Constitue’s30% of WBC5% of WBC Function Produce antibodies Responsible for immune response of body Phagocytic At site of infection enlarge & differentiate into macrophages, engulf microorganisms and remove debris. Scavengers