1. Orange Coast Medical Ventures

2. Overview Orange Coast Medical Ventures

3. Orange Coast Medical Ventures Overview OCMV was the first incubator to be facilitated by OCBIN*, a public benefit initiative of the University of California at Irvine. OCMV was established to commercialize the inventions of the faculty and researchers of UCI's Medical School and the Southern California Medical Community. * Orange County Business Incubation Network www.ocbin.orgwww.ocbin.org

4. Orange Coast Medical Ventures Board of Advisors Greg Ruehle CEO – Orange Coast Medical Ventures Paul DeRidder, M.D.Tech Coast Angels Shiv Grewal Partner - Stradling, Yocca, Carlson & Rauth Jim Armstrong Managing Director, Clearstone Venture Partners Steve Wilson Finance James Hill, M.D. J.D.Partner – McDermott Will & Emery LLP Doug BennettOversight Committee Chair

5. Orange Coast Medical Ventures Media Coverage  Getting Ready to Launch The Orange County Register May 10, 2007  The New Device Incubators Start-Up Magazine June, 2007  Incubator Innovators The Frank Peters Show Oct. 1, 2007

6. Orange Coast Medical Ventures About UC Irvine and UCI Medical Center

7. Orange Coast Medical Ventures UC Irvine Facts & Figures  U.S. News and World Report: 13 th Best Public University in U.S.  4 Nobel Laureates  $3.6 Billion Annual Economic Impact on OC  27,000 Students  1,900 Faculty  8,800 Staff  Founded in 1965

8. Orange Coast Medical Ventures UCI Invention Productivity

9. Orange Coast Medical Ventures The OCMV Ecosystem

10. Orange Coast Medical Ventures The OCMV Ecosystem Service Providers Corporate Partners Mentors Investors Economic Development U.C. Irvine OCMV Portfolio Company

11. Orange Coast Medical Ventures Corporate Partner Program  Participate in OCMV ecosystem Benefits from relationships with all constituencies Interact with UCI faculty & researchers

12. Orange Coast Medical Ventures Preferred Provider Program  Preferred provider to portfolio companies  Limited # of preferred providers per category  Participate in OCMV ecosystem Gain leads from other OCMV participants

13. Orange Coast Medical Ventures Mentor Program  Consists of Experienced Executives Investors Service Providers Corporate Partners Individuals  Pro Bono Guidance During Incubation  Potential for Employment or Contracts

14. Orange Coast Medical Ventures Paths to Commercialization Independent Entrepreneur Other OCMV Incubation Management Entrepreneur Entrepreneur with Mentoring Recruited/ Entrepreneur Funding Entrepreneur Introductions Provided Provided by Incubator Providers Entrepreneur Introductions Provided Preferred Providers Business Plan EntrepreneurPlan Review Process Co-developed with Incubator Dilution NoYes

15. Orange Coast Medical Ventures Investing In OCMV

16. Orange Coast Medical Ventures Investment Overview  OCMV is a Limited Partnership Invests in UCI and community inventions  Investors Own shares in OCMV’s LP Fund life: 3 years  Share price: $125K Variable discount for founding partners  Participation in OCMV ecosystem

17. Orange Coast Medical Ventures Investors Investment Allocation and Return OCMV L.P. Portfolio Companies Investment Returns Seed Capital Returns Inventors Share of License Fees Salary Government Agencies Corporate Partners U.C. IrvineInventors Salary Grants License and Contract Fees Normal Flow Optional Flow Returns Series A, B… Inventors Share of License Fees Grants Inventors Share of License Fees Grants Inventors Share of License Fees Grants Inventors Share of License Fees Grants Inventors Share of License Fees Grants Inventors Share of License Fees License and Contract Fees Grants Inventors Share of License Fees

18. Orange Coast Medical Ventures Two Portfolio Models Virtual Company  No payroll  Possible equity for contractors  No office/lab needs  IT equipment & hosting  Primary expense is T&E  Transactional legal expenses  Marketing expenses  Budget up to $10K/quarter Traditional Company  2-3 paid staff  May be directed research grant  May need offices/lab space  IT equipment and hosting  T&E  Transactional legal expenses  Marketing expenses  Budget up to $75K/quarter

19. Orange Coast Medical Ventures Vetting Process  Admission Criteria Intellectual property Market size and growth rate Scalability of company and technology Sustainability Key individuals - experience and skills  Evaluation Process Committee member becomes sponsor Sponsor works with company to create pitch Pitch delivered to full committee Committee accepts, rejects or defers

20. Orange Coast Medical Ventures Greg Ruehle, CEO c/o Office of Technology Alliances 380 University Tower University of California, Irvine Irvine, CA. 92697-7700 Office: 949-824-7295 Cell: 949-212-1983 Fax: 949-824-2899 E-mail: G355@aol.com