1. Review: Cells of the Immune System From Larsson and Karlsson (2005)

2. Review: Cells of the Immune System Larsson and Karlsson (2005)

3. Review: Myeloid cells Dendritic cell

4. Review: Myeloid cells Macrophages – phagocytes, antigen presenting cells (APCs), specialized cells different organs, secrete cytokines, produce complement proteins, can produce ROS/RNS. Neutrophils – phagoctyes, can produce ROS/RNS, secrete antimicrobial peptides, 1 st cell type to migrate from blood to infections, main targets are bacteria and fungi Basophils – secrete cytokines, involved in allergic response Eosinophils – phagocyte, targets parasites

5. Lymphocytes: T cells B cells Natural killer cells Review: Lymphocytes

6. B cells – naïve B cells: contain antigen binding receptor (or membrane bound antibody), once activated – memory cells: provides memory of antigen/antibody interaction; plasma cells: secrete soluble antibody T cells - contain antigen binding receptor (TCR) T H cells: secretes cytokines that activate B cells, T C cells, macrophages and others. T C cells: eliminates altered/damaged self cells (particularly those infected by viruses), fights tumors cells, secrete cytotoxins. T reg cells: helps suppress immune response, plays a role in tolerance. Review: Lymphocytes

7. Lymphoid cells Natural killer cells – distinct from T and B cells due to lack of an antigen binding receptor, similar in function to T C cells, macrophage activation, defense against viruses, fight tumor formation, secrete cytotoxins. Derived from both lymphoid and myeloid precursors Dendritic cells – phagoctyes, antigen presenting cells (APCs), can produce ROS, secrete proinflammatory cytokines, secrete antimicrobial peptides. Review: Cells of the Immune System

8. Review: Organs of the Immune System Primary and secondary lymphoid organs:

9. Review: Innate and adaptive immunity

10. Review: Innate Immune Response

11. Review: Adaptive Immune Response Antigen/Antibody interactions:  Antigen – any substance that binds specifically to an antibody or a T cell receptor (TCR).  Antibody- a protein (immunoglobulin) that recognizes a specific region (component) of an antigen. Properties of immunogenicity: Foreignness Molecular size Chemical composition/complexity Processing/presentation Host factors Dosage Route of entry

12. Antibody-Mediated Effector Functions Opsonization Assist and activate complement system ADCC