1. Vesicular Transport IV Chapter 13

2. 3 possible fates of receptor proteins in an epithelial cell

4. opiod receptor green transferin red

5. Low Density Lipoprotein particle transports cholesterol in the blood 1500 cholesterol molecules esterified to long chain fatty acids in one particle

6. Normal LDL receptors facilitate transport of cholesteryl esters in clathrin coated vesicles

7. Defective LDL receptor protein causes high levels of blood cholesterol and heart disease

8. cholesterol is released in lysosome

9. Blood Flow is not restricted until 70% of artery is blocked

10. Formation of plaque

12. Plaque formation in artery

13. Formation of liposomes beneath endothelial layer

14. Foam Cell with lipid storage bodies

15. Plaque

16. Plaque formation in rat aorta

17. Severe atherosclerosis of the aorta.

18. Storage diseases

19. Cholesteryl ester storage disease

21. Membrane bound granules filled with lipids

22. Cholesterol ester storage disease

23. Hurler disease

24. Hurler disease is a lysosomal storage deficiency

25. Symptoms of gargoylism Stunted Growth Mental Retardation blindness deafness heart and muscle dysfunction

27. Two ways for some lysosomal proteins to end up in lysosome

28. 3 best understood protein sorting pathways in the trans Golgi network

30. Hurler disease can be treated by adding lysosomal enzyme to blood stream

31. Alpha-1-antitrypsin deficiency

32. Normal protein export from the ER to Golgi

33. In alpha-1-antitrypdin deficiency export from ER does not occur

34. Alpha-1-anitrypsin accumulation in ER

35. Glycoprotein accumulation in liver cells

36. Globules of alpha-1-antitrypsin in liver cells

37. Failure of phagosomes and lysosomes to fuse Mycobacterium tuberculosis releases sulfatides

38. 3 pathways to degradation in the lysosome

39. Yeast in phagocytes stained with acridine orange become fluorescent as phagosomes fuse with lysosomes

40. Sulfatides prevent fusion of phagosomes with lysosomes

41. two toxoplasma in phagocyte 1 2 lysosomes