1. Monday March 5,12 AIM: How can we create a semiconservative model? DO NOW: Explain in two complete sentences what the DNA semi conservative model is. HOMEWORK: Text page 314 questions 16 and 17

2. http://www.mcb.harvard.edu/losic k/images/trombonefinald.swf

3. Figure 11.16 The Two New Strands Form in Different Ways

4. Why does the leading strand form continuously while the lagging strand is formed in fragments?

6. The Final product When the replication process is complete, two DNA molecules — identical to each other and identical to the original — have been produced. Each strand of the original molecule has remained intact as it served as the template for the synthesis of a complementary strand. This mode of replication is described as semi- conservative: one-half of each new molecule of DNA is old; one-half new.

7. Each DNA chromosome of the entire genome is replicated before division can occur Replicated chromosomes are now called sister chromatids

9. With all this drama, do you think errors occur during DNA replication? Nothing is perfect in this world so yes errors do occur. An error occurs only about once in each 10-100 billion bases.

10. Proofreading: DNA polymerase recognizes and repairs its own mistakes

11. Nonsense mutation Since there are 64 codons that specify 20 amino acids, sometimes a mutation still codes for the same amino acid