1. Control Circuit Design BIOSENSOR MICROPROCESSOR DEMULTIPLEXER MINIATURIZED MULTI-WELLED DRUG DELIVERY DEVICE TIMER POWER SOURCE

2. Thin-Film Battery Ion flow through electrolyte Electron flow through external circuit Flow driven by the redox reaction between anode and cathode

3. Cathode:LiCoO 2 Anode: Li metal Electrolyte: lithium phosphorus oxynitride Dimensions: 15  m thick 1 cm 2 area Battery Design Power capabilities: 3-4.2 V at 2 mA/cm 2 (~.2 mAh/cm 2 ) 25-37 C Rechargeable substrate cathode protective coating electrolyte anode current collector 15  m

4. Potential E(V) vs. SCE Release Mechanism: Gold Dissolution

5. Scaling in Electrochemistry X=  2D  D -diffusion coefficient  -time required for molecule to diffuse x -distance molecule diffuses Diffusion over 10  m is a millon times faster than diffusion over 1 cm

6. Power Requirements V=IRP=IV LESS than the battery capacity!

7. Final Device Dimensions 17mm x 17mm x 315  m Reservoirs: 400 total.05 mm spacing (bottom side) 25 nl volume Square pyramid side wall slope: 54  Fill opening: 500  m x 500  m Release end: 30  m x 30  m Gold caps: 50  m x 50  m x.3  m substrate cathode protective coating electrolyte anode current collector 15  m

8. Drug Delivery Schedule Depends on patient need 400 reservoirs - flexible type of drug amount of drug Example delivery 25 nl x day (1 reservoir) With 400 reservoirs, device lasts OVER A YEAR!

9.  The microchip for drug delivery described allows for storage and dependable controlled release of multiple drugs.  The microchip can be created by general microfabrication techniques.  This device can be self-contained and therefore eliminates the need for patient intervention.  The proposed device described (assuming one dose per day) can last over a year. Conclusions